Desmoglein 4 diversity and correlation analysis with coat color in goat

Zhao, Yong; H, Y; Cao, G. L.; He, Jianning; Na, R S; Zhao, Zhongquan; Jiang, Caode; Zhang, J H; Arlvd, S; Chen, L P; Qiu, X.Y.; Yuanxin, Huang

doi:10.4238/gmr.15017814

Cited by 6 publications

(3 citation statements)

References 33 publications

(33 reference statements)

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“…Furthermore, the DSG1 gene is involved in the communication of hair follicle cell and morphogenesis of hair follicle ( Hanakawa et al, 2004 ; Dong et al, 2013 ). The DSG4 gene affects wool traits and is responsible for coat color in Cashmere goats ( E et al, 2016 ). Furthermore, the DSG3 gene may have linked with additional fiber growth in the cashmere goats.…”

Section: Discussionmentioning

confidence: 99%

Sequence Characterization of DSG3 Gene to Know Its Role in High-Altitude Hypoxia Adaptation in the Chinese Cashmere Goat

et al. 2018

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The Tibetan cashmere goat is one of the main goat breeds used by people living in the plateau. It exhibits the distinct phenotypic characteristics observed in lowland goats, allowing them to adapt to the challenging conditions at high altitudes. It provides an ideal model for understanding the genetic mechanisms underlying high-altitude adaptation and hypoxia-related diseases. Our previous exome sequencing of five Chinese cashmere breeds revealed a candidate gene, DSG3 (Desmoglein 3), responsible for the high-altitude adaptation of the Tibetan goat. However, the whole DSG3 gene (44 kbp) consisting of 16 exons in the goat genome was not entirely covered by the exome sequencing. In this study, we resequenced all the 16 exons of the DSG3 gene in ten Chinese native goat populations. Twenty-seven SNP variants were found between the lowland and highland goat populations. The genetic distance (FST) of significant SNPs between the lowland and highland populations ranged from 0.42 to 0.58. By using correlation coefficient analysis, linkage disequilibrium, and haplotype network construction, we found three non-synonymous SNPs (R597E, T595I, and G572S) in exon 5 and two synonymous SNPs in exons 8 and 16 in DSG3. These mutations significantly segregated high- and low-altitude goats in two clusters, indicating the contribution of DSG3 to the high-altitude hypoxia adaptation in the Tibetan goat.

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Section: Discussionmentioning

confidence: 99%

Sequence Characterization of DSG3 Gene to Know Its Role in High-Altitude Hypoxia Adaptation in the Chinese Cashmere Goat

et al. 2018

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“… Zhou et al., 2016 2 DSG4 106052985-106078954 Haplotypes related with the color of the goat coat. E et al., 2016 2 CABLES1 1 102881201-102953764 An adapter protein that links cyclin-dependent kinase with nonreceptor tyrosine kinases and regulates the activity of Cdks by enhancing their Y15 phosphorylation. Huang et al., 2017 2 GATA6 102636810-102654409 Promotes hair follicle progenitor cell renewal.…”

Section: Resultsmentioning

confidence: 99%

“…The core haplotypes constructed by using the 3 most significant SNPs (rs14228181, rs14227093, and rs14230934) were ranging from 102.3 Mb to 106.4 Mb where many candidate genes were located. Previous studies demonstrated that DSG4 was related with the goat white and black color ( E et al., 2016 ), and GATA6 promotes hair follicle progenitor cell renewal ( Wang et al., 2017 ). Besides, the dietary intake of tyrosine could influence the color expression of the hair coat of adult dogs ( Watson et al., 2018 ), and the YES1 as a candidate of interested is a member of the Src family tyrosine kinases.…”

Section: Discussionmentioning

confidence: 99%

A quantitative trait locus on chromosome 2 was identified that accounts for a substantial proportion of phenotypic variance of the yellow plumage color in chicken

Huang

Song

et al. 2020

Poultry Science

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Chicken plumage color is an important economical trait in poultry breeding, as triple-yellow indigenous broilers are preferred over western commercial broilers in the Chinese market. However, the studies on the pigmentation of plumage coloration are relatively rare at present. Here, we performed a genome-wide mapping study on an F 2 intercross, whose 2 founders were one hybrid commercial line “High Quality chicken Line A” that originated from the Anak red chicken and one indigenous line “Huiyang Beard” chicken that is a classical “triple-yellow” Chinese indigenous breed. Moreover, we used an automatic colorimeter that can quantitatively assess the colorations in L∗, a∗, and b∗ values. One major quantitative trait locus ( QTL ) on chromosome 2 was thus identified by both genome-wide association and linkage analyses, which could explain 10 to 20% of the total phenotypic variance of the b∗ measurements of the back plumage color. Using linkage analysis, 2 additional QTL on chromosome 1 and 20 were also found to be significantly associated with the plumage coloration in this cross. With additional samples from Anak red and Huiyang Beard chickens as well as pooled resequencing data from the 2 founders of this cross, we then further narrowed down the QTL regions and identified several candidate genes, such as CABLES1, CHST11, BCL2L1, and CHD22. As the effects of QTL found in this study were substantial, quantitatively measuring the coloration rather than the descriptive measurements provides stronger statistical power for the analyses. In addition, this major QTL on chromosome 2 that was associated with feather pigmentation at the genome-wide level will facilitate the future chicken breeding for yellow plumage color. In conclusions, we mapped 3 associated QTL on chromosome 1, 2, and 20. The candidate genes identified in this study shed light in the genetic basis of yellow plumage color in chicken.

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Genomic inbreeding analysis reveals resilience and genetic diversity in Indian yak populations

Mahar,

Gurao,

Kumar

et al. 2024

Gene

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Desmoglein 4 diversity and correlation analysis with coat color in goat

Cited by 6 publications

References 33 publications

Sequence Characterization of DSG3 Gene to Know Its Role in High-Altitude Hypoxia Adaptation in the Chinese Cashmere Goat

Sequence Characterization of DSG3 Gene to Know Its Role in High-Altitude Hypoxia Adaptation in the Chinese Cashmere Goat

A quantitative trait locus on chromosome 2 was identified that accounts for a substantial proportion of phenotypic variance of the yellow plumage color in chicken

Genomic inbreeding analysis reveals resilience and genetic diversity in Indian yak populations

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