Desmoglein-3/γ-catenin and E-cadherin/ß-catenin differential expression in oral leukoplakia and squamous cell carcinoma

Kyrodimou, Marianthi; Andreadis, Dimitrios; Drougou, Angeliki; Amanatiadou, Elsa P.; Angelis, Lefteris; Barbatis, Calypso; Epivatianos, Apostolos; Vizirianakis, Ioannis S.

doi:10.1007/s00784-013-0937-z

Cited by 25 publications

(23 citation statements)

References 48 publications

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“…Besides, Kyrodimou et al (2013) and Gómez-Morales et al (2013) report that DSG3 is a marker for poorly differentiated OSCC and also for squamous differentiation in non-small-cell carcinomas. Consistent with these results, we observe that lose of DSG3 expression is associated with poor differentiation in ESCC, but not with lymphatic metastases and depth of tumor invasion, suggesting that the reduction of DSG3 expression is associated with loss of the ability of adhesion, as previously reported (Hartlieb et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Desmoglein 2 and Desmoglein 3 in Esophageal Squamous Cell Carcinoma

Fang

Gu²,

Liao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Desmoglein 2 and Desmoglein 3 in Esophageal Squamous Cell Carcinoma

Fang

Gu²,

Liao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…This reveals that E-cadherin might have a close association with the pathological features and biological behavior of tumors. E-cadherin not only plays an important role in cancer pathogenesis and metastasis, but is also greatly involved in the development of precancerous lesions, indicated by the fact that the abnormal expression of E-cadherin has been observed in oral leukoplakia and cervical intraepithelial neoplasia (15,16). Therefore, it is suggested that E-cadherin might be a suitable indicator for the early detection, diagnosis and prevention of tumors.…”

Section: Introductionmentioning

confidence: 99%

Expression of E-cadherin in oral lichen planus

2015

Experimental and Therapeutic Medicine

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Abstract. Oral lichen planus (OLP) is a common lesion of the oral mucosa that can progress to cancer. E-cadherin is involved in intercellular adherence and the pathogenesis, development and metastasis of tumors, and is considered to be an important indicator of tumor progression and prognosis. The aim of this study was to investigate the expression of E-cadherin in OLP in order to elucidate its role in the pathogenesis and malignant transformation of OLP and provide evidence to support the early diagnosis and treatment of OLP with malignant potential. OLP specimens (n=52) and samples of normal oral mucosa (n=41) as the control were collected. Immunohistochemical staining was conducted to reveal the expression of E-cadherin in the OLP samples and normal oral mucosa. It was observed that 25 of the 52 OLP specimens exhibited normal positive expression of E-cadherin and 27 exhibited abnormal positive expression, corresponding to an abnormal positive rate of 51.92%. In the normal oral mucosa group, 39 of the 41 cases exhibited normal positive expression and 2 exhibited abnormal positive expression. The abnormal positive rate in the normal oral mucosa was 4.88%, which was significantly lower than that in the OLP group. The significantly elevated rate of abnormal positive expression of E-cadherin in the OLP group indicates the involvement of E-cadherin in the malignant transformation of OLP and supports the malignant potential of OLP.

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“…After reading the titles and abstracts, 54 studies were considered potentially eligible and their full text was read by three reviewers. Seventeen articles met all inclusion criteria and were selected for this systematic review (5,(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). The selected articles were observational studies published between 2007 and 2018, all of them in English.…”

Section: Resultsmentioning

confidence: 99%

“…Anura et al (25) and Sharada et al (33) also evaluated tissue samples of oral submucosal fibrosis. Twelve studies included samples of oral squamous cell carcinoma (OSCC) for biomarker analysis, totaling 426 cases analyzed (5,18,21,23,24,(26)(27)(28)(31)(32)(33). Tissue (F) Cytokeratin-13 loss was found to be an independent diagnostic marker for high-grade dysplasia.…”

Section: Resultsmentioning

confidence: 99%

Prognostic value of the immunohistochemical detection of epithelial-mesenchymal transition biomarkers in oral epithelial dysplasia: A systematic review

Morais

Pinheiro²,

Lira³

et al. 2020

Med Oral

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Background: Oral potentially malignant disorders (OPMDs) comprise a range of clinical-pathological alterations that are frequently characterized as architectural and cytological derangements upon histological analysis. Epithelial-mesenchymal transition (EMT) has been proposed as a critical mechanism for the acquisition of the malignant phenotype in neoplastic epithelial processes. This study aims to systematically review the current findings on the immunohistochemical expression of epithelial-mesenchymal transition markers in oral potentially malignant disorders and to evaluate their possible application as biomarkers associated with the progression of oral epithelial dysplasias. Material and Methods: A systematic search was performed in the following databases: PubMed, EMBASE, Chinese BioMedical Literature Database, and Cochrane Library. Articles that evaluated the relationship between the expression of EMT markers and the degree of oral epithelial dysplasia were selected for the systematic review. The quality of each eligible study was evaluated by independent reviewers that used operationalized prognostic biomarker reporting guidelines (REMARK). Results: Seventeen articles met all inclusion criteria and were selected. The EMT markers analyzed exhibited an important association with the prognosis of the cases evaluated. The results showed a progressive increase in the expression of nuclear transcription factors and markers of mesenchymal differentiation, as well as negative regulation of epithelial and cell adhesion markers, according to the stage of oral epithelial dysplasia.

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Desmoglein-3/γ-catenin and E-cadherin/ß-catenin differential expression in oral leukoplakia and squamous cell carcinoma

Abstract: The observed alterations of their expression suggest a role of Dsg3 and γ-catenin (additionally to E-cadherin/β-catenin) as biomarkers of malignant transformation risk of oral dysplasia and the biological behavior (aggressiveness) of oral cancer, respectively.

Cited by 25 publications

References 48 publications

Prognostic Significance of Desmoglein 2 and Desmoglein 3 in Esophageal Squamous Cell Carcinoma

Prognostic Significance of Desmoglein 2 and Desmoglein 3 in Esophageal Squamous Cell Carcinoma

Expression of E-cadherin in oral lichen planus

Prognostic value of the immunohistochemical detection of epithelial-mesenchymal transition biomarkers in oral epithelial dysplasia: A systematic review

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