Desmoglein-3 overexpression in oral squamous cell carcinoma is associated with metastasis formation and early recurrence: An immunohistochemical study

Troeltzsch, Matthias; Künzel, Verena; Haidari, Selgai; Troeltzsch, Markus; Otto, Sven; Ehrenfeld, Michael; Probst, Florian; Knösel, Thomas

doi:10.1016/j.jcms.2021.11.015

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…Among the two cuproptosis patterns, the most prognostic DEGs were DSG2, C7, DUSP9, PPARG, STK26, GSTCD, MIPOL1 , and RYR2 . DSG‐3 overexpression is significantly associated with poor differentiation and metastasis in OSCC 22 . PPARG regulates fatty acid metabolism‐related genes in OSCC 23 .…”

Section: Discussionmentioning

confidence: 99%

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Landscape and the immune patterns of cuproptosis in oral squamous cell carcinoma

Yuan,

Li,

et al. 2023

J Oral Pathology Medicine

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BackgroundOral squamous cell carcinoma is an increasingly prevalent cancer type characterized by high incidence and mortality rates. Its early detection is challenging, primarily because of the absence of early molecular markers. Cuproptosis is a novel regulatory mechanism of cell death with implications in various cancers. In this study, we aimed to study cuproptosis‐related genes in oral squamous cell carcinoma to identify their prognostic value.MethodsBy analyzing genomic, bulk RNA‐seq, and single‐cell RNA‐seq data, we investigated 13 cuproptosis‐related genes in The Cancer Genome Atlas‐Oral Squamous Cell Carcinoma dataset and Gene Expression Omnibus repository (GSE172577).ResultsATP7A, ATP7B, and DLST were the most frequently mutated genes, with nine of our studied genes associated with overall survival. Single‐cell analysis was conducted to identify cuproptosis‐related tumor cells in oral squamous cell carcinoma, which revealed two distinct patterns based on the expression of cuproptosis‐related genes. These patterns exhibit differences in genetic alterations and tumor immune microenvironment. Finally, we developed a cuproptosis index using a random forest algorithm based on cuproptosis pattern‐related genes in which higher levels were linked to poorer prognosis.ConclusionOur findings provide valuable insights into the mechanisms underlying oral squamous cell carcinoma‐associated cuproptosis.

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Section: Discussionmentioning

confidence: 99%

“…DSG-3 overexpression is significantly associated with poor differentiation and metastasis in OSCC. 22 PPARG regulates fatty acid metabolism-related genes in OSCC. 23 RYR2 mutations have been found in 23.3% of OSCC cases associated with tobacco consumption, 24 and the loss of RYR2 expression is responsible for malignant conversion.…”

Section: Discussionmentioning

confidence: 99%

Landscape and the immune patterns of cuproptosis in oral squamous cell carcinoma

Yuan,

Li,

et al. 2023

J Oral Pathology Medicine

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Desmoglein 3 (Dsg3) expression in cancer: A tissue microarray study on 15,869 tumors

Viehweger

Azem

Gorbokon

et al. 2022

Pathology - Research and Practice

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Prognostic model based on telomere-related genes predicts the risk of oral squamous cell carcinoma

Yue

Xue

2023

BMC Oral Health

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Background This study investigated a potential prognostic model based on telomere-related genes (TRGs) for the clinical prediction of oral squamous cell carcinoma (OSCC). Methods Gene expression data and associated clinical phenotypes were obtained from online databases. Differentially expressed (DE)-TRGs were identified between OSCC and normal samples, followed by protein-protein interaction and enrichment analyses. Subsequently, the prognostic genes explored based on the DE-TRGs and survival data were applied in the establishment of the current prognostic model, and an integrated analysis was performed between high- and low-risk groups using a prognostic model. The expression of certain prognostic genes identified in the present study was validated using qPCR analysis and/or western blot in OSCC cell lines and clinical samples. Results 169 DE-TRGs were identified between the OSCC samples and controls. DE-TRGs are mainly involved in functions such as hypoxia response and pathways such as the cell cycle. Eight TRGs (CCNB1, PDK4, PLOD2, RACGAP1, MET, PLK1, KPNA2, and CCNA2) associated with OSCC survival and prognosis were used to construct a prognostic model. qPCR analysis and western blot showed that most of the eight prognostic genes were consistent with the current bioinformatics results. Analysis of the high- and low-risk groups for OSCC determined by the prognostic model showed that the current prognostic model was reliable. Conclusions A novel prognostic model for OSCC was constructed by TRGs. PLOD2 and APLK1 may participate in the progression of OSCC via responses to hypoxia and cell cycle pathways, respectively. TRGs, including KPNA2 and CCNA2, may serve as novel prognostic biomarkers for OSCC.

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Desmoglein-3 overexpression in oral squamous cell carcinoma is associated with metastasis formation and early recurrence: An immunohistochemical study

Cited by 5 publications

References 28 publications

Landscape and the immune patterns of cuproptosis in oral squamous cell carcinoma

Landscape and the immune patterns of cuproptosis in oral squamous cell carcinoma

Desmoglein 3 (Dsg3) expression in cancer: A tissue microarray study on 15,869 tumors

Prognostic model based on telomere-related genes predicts the risk of oral squamous cell carcinoma

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