Desmoglein-2 is overexpressed in non-small cell lung cancer tissues and its knockdown suppresses NSCLC growth by regulation of p27 and CDK2

Cai, Feng; Zhu, Qingqing; Miao, Yingying; Shen, Simei; Su, Xin; Shi, Yi

doi:10.1007/s00432-016-2250-0

Cited by 59 publications

(58 citation statements)

References 38 publications

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“…32 A study showed that downregulation of DSG2 expression in colonic adenocarcinoma cell lines led to growth inhibition both in vitro and in vivo, which highlighted the essential role of the cell adhesion protein in controlling the growth of cancer cell. Consistent with these findings that DSG2 was found to be overexpressed in skin cancer, 33 lung cancer, 34 and head and neck cancer. 35 The possible mechanism is downregulated DSG2 inhibited epidermal growth factor receptor (EGFR) signaling and cell proliferation through altered phosphorylation of EGFR and downstream extracellular signalregulated kinase activation in parallel with inhibited EGFR receptor internalization.…”

Section: Discussionsupporting

confidence: 83%

Integrative prognostic subtype discovery in high‐grade serous ovarian cancer

Xie

Hou

et al. 2019

J of Cellular Biochemistry

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Objective We sought to identify novel molecular subtypes of high‐grade serous ovarian cancer (HGSC) by the integration of gene expression and proteomics data and to find the underlying biological characteristics of ovarian cancer to improve the clinical outcome. Methods The iCluster method was utilized to analysis 131 common HGSC samples between TCGA and Clinical Proteomic Tumor Analysis Consortium databases. Kaplan‐Meier survival curves were used to estimate the overall survival of patients, and the differences in survival curves were assessed using the log‐rank test. Results Two novel ovarian cancer subtypes with different overall survival (P = .00114) and different platinum status (P = .0061) were identified. Eighteen messenger RNAs and 38 proteins were selected as differential molecules between subtypes. Pathway analysis demonstrated arrhythmogenic right ventricular cardiomyopathy pathway played a critical role in the discrimination of these two subtypes and desmosomal cadherin DSG2, DSP, JUP, and PKP2 in this pathway were overexpression in subtype I compared with subtype II. Conclusion Our study extended the underlying prognosis‐related biological characteristics of high‐grade serous ovarian cancer. Enrichment of desmosomal cadherin increased the risk for HGSC prognosis among platinum‐sensitive patients, the results guided the revision of the treatment options for platinum‐sensitive ovarian cancer patients to improve outcomes.

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Section: Discussionsupporting

confidence: 83%

Integrative prognostic subtype discovery in high‐grade serous ovarian cancer

Xie

Hou

et al. 2019

J of Cellular Biochemistry

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“…In particular, desmosomal cadherin is known to promote cell growth, migration, and invasion through regulation of the signaling of cyclin-dependent kinase 2 (CDK-2), activator protein 1 (AP-1), and protein kinase C (PKC). 19,20 The expression of E-cadherin is limited to the epithelial cells of pterygium head and not detected in the normal cornea and conjunctiva. 21 Thus, our findings indicate that desmosomes between PECs not only provide hyperadhesive intercellular junctions, but may also facilitate the signal transduction mediating aggregation-dependent cell survival.…”

Section: Discussionmentioning

confidence: 99%

Induction of Apoptosis in Pterygium Cells by Antagonists of Growth Hormone–Releasing Hormone Receptors

Qin

Chu

Huang

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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The aim of the study was to investigate the signaling of growth hormone-releasing hormone receptor (GHRH-R) in the pathogenesis of pterygium and determine the apoptotic effect of GHRH-R antagonist on pterygium epithelial cells (PECs). METHODS. Fourteen samples of primary pterygium of grade T3 with size of corneal invasion ‡ 4 mm were obtained for investigation by histology, immunofluorescence, electron microscopy, explant culture, and flow cytometry. RESULTS. We found that PECs were localized in the basal layer of the epithelium in advancing regions of the head of pterygium. These cells harbored clusters of rough endoplasmic reticulum, ribosomes, and mitochondria, which were consistent with their aggressive proliferation. Immunofluorescence studies and Western blots showed that GHRH-R and the downstream growth hormone receptor (GH-R) were intensively expressed in PECs. Their respective ligands, GHRH and GH, were also elevated in the pterygium tissues as compared to conjunctival cells. Explanted PECs were strongly immunoreactive to GHRH-R and exhibited differentiation and proliferation that led to lump formation. Treatment with GHRH-R antagonist MIA-602 induced apoptosis of PECs in a dose-dependent manner, which was accompanied by a downregulation of ERK1 and upregulation of Caspase 3 expression. CONCLUSIONS. Our results revealed that GHRH-R signaling is involved in survival and proliferation of PECs and suggest a potential therapeutic approach for GHRH-R antagonist in the treatment of pterygium.

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“…The most abundant protein is desmoglein-2. It has been reported that desmoglein-2 is overexpressed in NSCLC tissues and induce NSCLC growth by regulating p27 and CDK2 [105]. The next most enriched protein is EGFR.…”

Section: Lung Cancermentioning

confidence: 99%

“…Drug and chemotherapy resistance [97] TGF-β1 Drug resistance [98] TPRC5 Chemotherapy resistance [99] UCH-L1 Chemotherapy resistance [100] Nephronectin Induce tumor mestasis [101] Caveolin-1 Enriched in metastasized cancer cell [36] Periostin Enriched in metastasized cancer cell [102] Myoferlin Enriched in metastasized cancer cell [31] Lung Cancer Mucin 5AC, B Lung cancer relapse and metastasis [103,104] Desmoglein-2 overspressed in non small cell lung cancer and induce cell growth [105] EGFR Oncogene in lung cancer [106,111,113,114] LRG1 Induce angiogenesis [108] Tim-3 Induce anti-tumor immune response [110] NY-SEO-1 Overexpressed in lung cancer [111] [111] EpCam Overexpressed in lung cancer [111] SGRN Overexpressed in lung cancer [112] TPM3 Overexpressed in lung cancer [112] THBS1 Overexpressed in lung cancer [112] HUWE1 Overexpressed in lung cancer [112] MUC 1 Overexpressed in lung cancer [112] Colon Cancer…”

Section: Gstp1mentioning

confidence: 99%

Exploring the key communicator role of exosomes in cancer microenvironment through proteomics

Kim

Cho

2019

Proteome Sci

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There have been many attempts to fully understand the mechanism of cancer behavior. Yet, how cancers develop and metastasize still remain elusive. Emerging concepts of cancer biology in recent years have focused on the communication of cancer with its microenvironment, since cancer cannot grow and live alone. Cancer needs to communicate with other cells for survival, and thus they secrete various messengers, including exosomes that contain many proteins, miRNAs, mRNAs, etc., for construction of the tumor microenvironment. Moreover, these intercellular communications between cancer and its microenvironment, including stromal cells or distant cells, can promote tumor growth, metastasis, and escape from immune surveillance. In this review, we summarized the role of proteins in the exosome as communicators between cancer and its microenvironment. Consequently, we present cancer specific exosome proteins and their unique roles in the interaction between cancer and its microenvironment. Clinically, these exosomes might provide useful biomarkers for cancer diagnosis and therapeutic tools for cancer treatment.

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Desmoglein-2 is overexpressed in non-small cell lung cancer tissues and its knockdown suppresses NSCLC growth by regulation of p27 and CDK2

Abstract: This study revealed the importance of Dsg2 in suppression of NSCLC development and progression. Further studies will explore whether restoration of Dsg2 expression is a novel strategy in control of NSCLC.

Cited by 59 publications

References 38 publications

Integrative prognostic subtype discovery in high‐grade serous ovarian cancer

Integrative prognostic subtype discovery in high‐grade serous ovarian cancer

Induction of Apoptosis in Pterygium Cells by Antagonists of Growth Hormone–Releasing Hormone Receptors

Exploring the key communicator role of exosomes in cancer microenvironment through proteomics

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