Desmiflavasides A and B: Two new bioactive pregnane glycosides from the sap of Desmidorchis flava

Raees, Muhammad Adil; Hussain, Hidayat; Rehman, Najeeb Ur; Khan, Husain Yar; Abbas, Ghulam; Al‐Rawahi, Ahmed; Elyassi, Ali; Al-Amri, Issa; Green, Ivan R.; Al-Broumi, Mohammed; Mahmood, Talat; Al‐Harrasi, Ahmed

doi:10.1016/j.phytol.2015.03.013

Cited by 12 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Values are presented as Mean ± SD of four duplicates. Cells (1×10 5 /well) were seeded and allowed to adhere firmly in cell culture medium with 10% FBS [12]. Urease, α-glucosidase, and Acetyl Cholinesterase Enzyme Inhibition Bioassays Urease enzyme inhibition activity was performed according to the method as described [13].…”

Section: Extraction and Fractionationmentioning

confidence: 99%

Phytochemical and pharmacological investigation of Teucrium muscatense

Rehman

Al-Sahai

Hussain

et al. 2017

ijpm

Self Cite

View full text Add to dashboard Cite

The effect of enzyme inhibition, anticancer, antifungal, antioxidants activities of the extracts of Teucrium muscatense obtained with different organic solvents was investigated. Chloroform fraction exhibited promising inhibition (64%) with IC50 value (390 ± 2.0 μg/mL) against urease, while other fractions displayed moderate activity. In case of α-glucosidase and acetyl cholinesterase enzyme inhibition assays, all fractions were found inactive at a concentration of 1.0 mg/mL. The n-hexane fraction of Teucrium muscatense exhibited highest anticancer activity against breast cancer cell (MDAMB231) line at high (100 µg/mL) concentration and also inhibited the growth of F. oxysporum up to 64.3% in case of antifungal activity. EtOAc fraction showed highiest DPPH (70.6%) and ABTS (76.7%) radical scavenging activity at highest concentration (1000 μg/mL). Bioassay guided isolation of EtOAc fraction afforded two flavonoids (1 and 2). Both compounds showed highiest ABTS activity and could be a significant markers in the EtOAc fraction. Anti-lipid peroxidation assay was also performed in which aqueous fraction showed highest percentage of 73.2% at higher concentration (1000 μg/mL) followed by n-BuOH (64.1%) and EtOAc (51.4%) fractions. GC/MS analysis of the essential oil of T. mascatense showed higher percentage of linalool (34.18%), limonene (13.45%), linalyl acetate (10.04%), and β-eudesmol (9.21%). Proximate composition of Teucrium muscatense showed that it contained high amount of ash (19.6%), protein (10.3%), and fiber (17.5%).

show abstract

Section: Extraction and Fractionationmentioning

confidence: 99%

Phytochemical and pharmacological investigation of Teucrium muscatense

Rehman

Al-Sahai

Hussain

et al. 2017

ijpm

Self Cite

View full text Add to dashboard Cite

show abstract

“…As described by Raees et al, some novel pregnane glycosides from Desmidorchis flava possess antiproliferative effects against breast and ovarian cancer cell lines [ 49 , 50 ]. Compounds 4 – 7 ( Figure 3 A) showed cytotoxicity on MDA-MB 231 and SKOV-3 cancer cells [ 51 ].…”

Section: Novel Glycosidesmentioning

confidence: 99%

Efforts in Bioprospecting Research: A Survey of Novel Anticancer Phytochemicals Reported in the Last Decade

et al. 2022

View full text Add to dashboard Cite

Bioprospecting natural products to find prominent agents for medical application is an area of scientific endeavor that has produced many clinically used bioactive compounds, including anticancer agents. These compounds come from plants, microorganisms, and marine life. They are so-called secondary metabolites that are important for a species to survive in the hostile environment of its respective ecosystem. The kingdom of Plantae has been an important source of traditional medicine in the past and is also enormously used today as an exquisite reservoir for detecting novel bioactive compounds that are potent against hard-to-treat maladies such as cancer. Cancer therapies, especially chemotherapies, are fraught with many factors that are difficult to manage, such as drug resistance, adverse side effects, less selectivity, complexity, etc. Here, we report the results of an exploration of the databases of PubMed, Science Direct, and Google Scholar for bioactive anticancer phytochemicals published between 2010 and 2020. Our report is restricted to new compounds with strong-to-moderate bioactivity potential for which mass spectroscopic structural data are available. Each of the phytochemicals reported in this review was assigned to chemical classes with peculiar anticancer properties. In our survey, we found anticancer phytochemicals that are reported to have selective toxicity against cancer cells, to sensitize MDR cancer cells, and to have multitarget effects in several signaling pathways. Surprisingly, many of these compounds have limited follow-up studies. Detailed investigations into the synthesis of more functional derivatives, chemical genetics, and the clinical relevance of these compounds are required to achieve safer chemotherapy.

show abstract

“…Atoprotective and antidiabetic [56] Anticancer [55] Antiobesity [57] Antinociceptive [62] Antiobesogenic and antiatherosclerotic [58] Effect on food intake, appetite, and anthropometry [108] Caralluma flava (Desmidorchis flava) Antiproliferation [109] Antioxidant [110] Caralluma russelliana Antitrypanosomal [87] Caralluma stalagmifera Antioxidant [69] Antiadipogenesis [100] Antiproliferative properties [67] Immunostimulating [70] Anti-inflammatory and antiarthritic [111] Caralluma stalagmifera var. longipetala Antiadipogenesis [100] Antioxidant [69] Antiproliferative properties [67] Immunostimulating [70] Caralluma tuberculata Hypoglycemic and hypolipidemic [80] Neuroprotective [112] Antihypertensive [82] Antioxidant [81,113] Antifungal, antioxidant, cytotoxic, phytotoxic [86] Phytotoxic and antioxidant [84] Sedative, muscle relaxant, and antinociceptive [85] Antifungal, antibacterial, and phytotoxic [114] Antiproliferative [115] Antiplasmodial and antitrypanosomal [87] Anti-inflammatory [116] Caralluma umbellata Nephroprotective and antioxidant [88] Antibacterial [89] Cytotoxic [68] Antiadipogenesis [100] Antioxidant [69] Antiproliferative properties [67] Nephroprotective [90] Antioxidant [91] Hepatoprotective [92]…”

Section: Name Of the Plant Biological Activity Referencesmentioning

confidence: 99%

Untitled

Nadh¹

2018

AJP

View full text Add to dashboard Cite

In history, medicinal plants were proven as a source of active compounds with therapeutic applications, and at present, they are an important collection for the discovery of novel drug leads. Caralluma is a genus used as traditional medicine. The present article thoroughly reviewed about the classification of Caralluma into subgenera, number of its species, its distribution in different parts of the world, and pharmacological activities exhibited by different species of Caralluma.

show abstract

Desmiflavasides A and B: Two new bioactive pregnane glycosides from the sap of Desmidorchis flava

Cited by 12 publications

References 14 publications

<p>Phytochemical and pharmacological investigation of <em>Teucrium muscatense</em></p>

<p>Phytochemical and pharmacological investigation of <em>Teucrium muscatense</em></p>

Efforts in Bioprospecting Research: A Survey of Novel Anticancer Phytochemicals Reported in the Last Decade

Untitled

Contact Info

Product

Resources

About