Desipramine Plasma Concentration and Antidepressant Response

Nelson, J. Craig

doi:10.1001/archpsyc.1982.04290120049010

Cited by 79 publications

(6 citation statements)

References 14 publications

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“…Scandinavian investigators (Asberg et al, 1971;Kragh-Sorensen et al, 1973) identified a therapeutic range for nortriptyline; furthermore, elderly depressives required serum concentrations comparable to those effective in younger adults. Similar findings have been reported for another secondary amine TCA, desipramine (Nelson et al, 1982); again, elderly melancholics appear to require blood levels comparable to those needed by young adults (Nelson et al, 1985). These studies indicate that 'adequacy' of pharmacologic treatment plays a critical role in determining the clinical response to treatment with TCA's.…”

Section: Adequacy Of Somatic Treatment O F the Index Episodesupporting

confidence: 75%

Effects of somatic treatment in longitudinal studies of geriatric depression

1991

Int J Geriat Psychiatry

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Section: Adequacy Of Somatic Treatment O F the Index Episodesupporting

confidence: 75%

Effects of somatic treatment in longitudinal studies of geriatric depression

1991

Int J Geriat Psychiatry

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“…5). Serum DMI levels were within the therapeutic range of 37–163 ng/mL [28] following chronic drug treatment (Fig. 5A).…”

Section: Resultsmentioning

confidence: 99%

Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABAA receptors

Benham

Hewage

Suckow

et al. 2017

Behavioural Brain Research

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Deficits in neuronal inhibition via gamma-aminobutyric acid (GABA) type A receptors (GABAA-Rs) are implicated in the pathophysiology of major depressive disorder and the therapeutic effects of current antidepressant treatments, however, the relevant GABAA-R subtype as defined by its alpha subunit is still unknown. We previously reported anxiety- and depressive-like behavior in alpha2+/− and alpha2−/− mice, respectively (Vollenweider, 2011). We sought to determine whether this phenotype could be reversed by chronic antidepressant treatment. Adult male mice received 4 or 8 mg/kg fluoxetine or 53 mg/kg desipramine in their drinking water for four weeks before undergoing behavioral testing. In the novelty suppressed feeding test, desipramine had anxiolytic-like effects reducing the latencies to bite and to eat the pellet in both wild-type and alpha2+/− mice. Surprisingly, 4mg/kg fluoxetine had anxiogenic-like effects in alpha2+/− mice increasing latency to bite and to eat while 8mg/kg fluoxetine increased the latency to eat in both wild-type and alpha2+/− mice. In the forced swim and tail suspension tests, chronic desipramine treatment increased latency to immobility in wild-type and alpha2−/− mice. In contrast, chronic fluoxetine treatment increased immobility in alpha2−/− mice in both tasks while generally having no effect in wild-type mice. These findings suggest that in preclinical paradigms of anxiety and behavioral despair the antidepressant-like effects of desipramine are independent of alpha2-containing GABAA-Rs, while a reduction in alpha2 expression leads to an increased sensitivity to anxiogenic- and prodepressant-like effects with chronic fluoxetine treatment, pointing to a potential role of alpha2-containing GABAA-Rs in the response to serotonin-selective antidepressants.

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“…Studies of both nortriptyline [61,62] and desipramine [63] have, in general, demonstrated curvilinear con-centration-response relationships, with optimum ranges of 50±150 ng ml x1 (200±600 nmol l x1 ) and 100±160 ng ml x1 (400±650 nmol l x1 ), respectively, and response rates of 70% and 59%, respectively, within these ranges [54]. A recent double-blind 3 year maintenance study [64] of two ®xed plasma concentration groups, i.e.…”

Section: Sampling Times and Intervalsmentioning

confidence: 99%

Therapeutic drug monitoring of psychotropic medications

Mitchell

2000

Brit J Clinical Pharma

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Therapeutic drug monitoring (TDM) of a number of psychotropic medications has proven to be of value, enabling minimization of the limitations of considerable genetic variability in their metabolism and the high rates of poor compliance with many psychiatric disorders. Therapeutic ranges have been established for lithium, some of the tricyclic antidepressants, and clozapine. TDM has also been shown to be useful in avoiding toxicity (as many psychotropics have narrow therapeutic indices), particularly that due to interactions with other compounds.

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Desipramine Plasma Concentration and Antidepressant Response

Cited by 79 publications

References 14 publications

Effects of somatic treatment in longitudinal studies of geriatric depression

Effects of somatic treatment in longitudinal studies of geriatric depression

Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABAA receptors

Therapeutic drug monitoring of psychotropic medications

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