Designing vaccine candidates against dengue virus by in silico studies on structural and nonstructural domains

Shoushtari, M Mahmoudian; Mafakher, Ladan; Rahmati, Saman; Salehi‐Vaziri, Mostafa; Arashkia, Arash; Roohvand, Farzin; Teimoori‐Toolabi, Ladan; Azadmanesh, Kayhan

doi:10.1016/j.mcp.2022.101818

Cited by 4 publications

(2 citation statements)

References 62 publications

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“…This makes it difficult for RA protein to be used in a vaccine. Bioinformatics provides an analytical tool used to identify vaccine antigens in Staphylococcus aureus [ 28 ], E. coli [ 25 ], Burkholderia pseudomallei [ 22 ], and other pathogens [ 21 , 23 , 24 ]. Therefore, in this paper, bioinformatics tools were used to analyze the RA outer membrane protein YaeT.…”

Section: Discussionmentioning

confidence: 99%

In Silico Analysis and Immune Response of YaeT Protein Against Riemerella anatipestifer in Ducks

Guan

Yang

Liao

et al. 2023

Appl Biochem Biotechnol

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Section: Discussionmentioning

confidence: 99%

In Silico Analysis and Immune Response of YaeT Protein Against Riemerella anatipestifer in Ducks

Guan

Yang

Liao

et al. 2023

Appl Biochem Biotechnol

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“…With the use of these tools, the principle of the 3 Rs (replace, reduce and refine) is applied to the development of vaccine targets, and their prediction of efficiency and safety [ 6 ]. In recent years, the use of bioinformatics tools has allowed the design and selection of vaccine candidates for coronavirus [ 6 , 7 ], dengue [ 8 ], Mycoplasma pneumonia [ 9 ], malaria [ 10 ], among many others.…”

Section: Introductionmentioning

confidence: 99%

In silico EsxG EsxH rational epitope selection: Candidate epitopes for vaccine design against pulmonary tuberculosis

2023

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Rational design of new vaccines against pulmonary tuberculosis is imperative. Early secreted antigens (Esx) G and H are involved in metal uptake, drug resistance, and immune response evasion. These characteristics make it an ideal target for rational vaccine development. The aim of this study is to show the rational design of epitope-based peptide vaccines by using bioinformatics and structural vaccinology tools. A total of 4.15 μs of Molecular Dynamics simulations were carried out to describe the behavior in solution of heterodimer, single epitopes, and epitopes loaded into MHC-II complexes. In order to predict T and B cell epitopes for antigenic activation, bioinformatic tools were used. Hence, we propose three epitopes with the potential to design pulmonary tuberculosis vaccines. The possible use of the proposed epitopes includes subunit vaccines, as a booster in BCG vaccination to improve its immune response, as well as the generation of antibodies that interfere with the Mycobacterium tuberculosis homeostasis, affecting its survival.

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Computational designing of the ligands of Protein L affinity chromatography based on molecular docking and molecular dynamics simulations

Rahmati,

Bagherzadeh,

Arab

et al. 2023

Journal of Biomolecular Structure and Dynamics

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Designing vaccine candidates against dengue virus by in silico studies on structural and nonstructural domains

Cited by 4 publications

References 62 publications

In Silico Analysis and Immune Response of YaeT Protein Against Riemerella anatipestifer in Ducks

In Silico Analysis and Immune Response of YaeT Protein Against Riemerella anatipestifer in Ducks

In silico EsxG EsxH rational epitope selection: Candidate epitopes for vaccine design against pulmonary tuberculosis

Computational designing of the ligands of Protein L affinity chromatography based on molecular docking and molecular dynamics simulations

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