Designing tragacanth gum based sterile hydrogel by radiation method for use in drug delivery and wound dressing applications

Singh, Baljit; Varshney, Lalit; Francis, Sanju; Rajneesh, -

doi:10.1016/j.ijbiomac.2016.03.051

Cited by 74 publications

(23 citation statements)

References 63 publications

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“…XRD pattern of samples showed a broad peak (at 2θ about 20°) due to amorphous nature of GT which consistent with the reported studies (Singh & Sharma, 2017;Singh, Varshney, Francis, & Rajneesh, 2016). Bassorin separation from GT resulted in lower broad peak intensity with an amorphous nature.…”

Section: Xrd Analysessupporting

confidence: 90%

Physicochemical, Rheological and Structural Characteristics of Alcohol Precipitated Fraction of Gum Tragacanth

Kurt¹

2018

Food Health

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Obtaining specific polysaccharide of gum by separating other parts appears to be an approach to get a hydrocolloid with a higher quality and new functional properties. Therefore, gum tragacanth (GT) was used for these aims. The characterization of alcohol precipitated part of GT were performed in terms of physico-chemical compositions (moisture, ash, protein, color and transparency); rheological behaviors aqueous solutions at different concentration, temperature, pH, presence of salt and sucrose; and structural characterization (FTIR, XRD, DSC and SEM). Applied process has no effect on sucrose its chemical compositions which is important for preserving of progressing application. Clearer solution was obtained for purified sample which was important for sensorial properties of end-product. Rheological experiments indicated that separation insoluble part (bassorin) from GT increased viscosity and improved the stability to the different environmental conditions. FTIR experiment results confirmed that tragacanthin and bassorin is physically mixture not chemically bonded. The improvement of thermal stability of GT was also observed by DSC as a result of bassorin separation. The results suggest that extraction soluble part of GT resulted in higher rheological and structural characteristics which may help to widen its application.

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Section: Xrd Analysessupporting

confidence: 90%

Physicochemical, Rheological and Structural Characteristics of Alcohol Precipitated Fraction of Gum Tragacanth

Kurt¹

2018

Food Health

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“…2 So, it is easy for hydrogels to selectively load drug molecules with controlled release at the desirable site and to offer accurate prolonged release. 31,[129][130][131] The antibiotics in common use for antimicrobial hydrogels are as follows.…”

mentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

285

197

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The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an imminent global public health problem. Local application of antibiotics might be a solution. In local application, materials need to act as the drug delivery system. The drug delivery system should be biodegradable and prolonged antibacterial effect should be provided to satisfy clinical demand. Hydrogel is a promising material for local antibacterial application. Hydrogel refers to a kind of biomaterial synthesized by a water-soluble natural polymer or a synthesized polymer, which turns into gel according to the change in different signals such as temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high hydrophilicity, unique three-dimensional network, fine biocompatibility and cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery in antimicrobial areas. In this review, studies from the past 5 years were reviewed, and several types of antimicrobial hydrogels according to different ingredients, different preparations, different antimicrobial mechanisms, different antimicrobial agents they contained and different applications, were summarized. The hydrogels loaded with metal nanoparticles as a potential method to solve antibiotic resistance were highlighted. Finally, future prospects of development and application of antimicrobial hydrogels are suggested.

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“…The composition PVA-cl-GT-co-SA-based wound dressing films exhibited good absorption of wound fluid and showed blood-compatibility and non-thrombogenic nature. The obtained wound dressing films showed good gas permeability, impermeability to microorganisms, and controlled release of moxifloxacin drug for 24 h of time duration without burst release [198]. Further, Aloe Vera extract encapsulated and aluminum ions (Al 3+ ) crosslinked GT spherical-shaped nanocapsules showed relative great antimicrobial behaviors as 84%, 91%, and 80% reduction against Escherichia coli, S. aureus, and Candida albicans, respectively.…”

Section: Wound Dressingmentioning

confidence: 95%

Recent Advances in Natural Gum-Based Biomaterials for Tissue Engineering and Regenerative Medicine: A Review

et al. 2020

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The engineering of tissues under a three-dimensional (3D) microenvironment is a great challenge and needs a suitable supporting biomaterial-based scaffold that may facilitate cell attachment, spreading, proliferation, migration, and differentiation for proper tissue regeneration or organ reconstruction. Polysaccharides as natural polymers promise great potential in the preparation of a three-dimensional artificial extracellular matrix (ECM) (i.e., hydrogel) via various processing methods and conditions. Natural polymers, especially gums, based upon hydrogel systems, provide similarities largely with the native ECM and excellent biological response. Here, we review the origin and physico-chemical characteristics of potentially used natural gums. In addition, various forms of scaffolds (e.g., nanofibrous, 3D printed-constructs) based on gums and their efficacy in 3D cell culture and various tissue regenerations such as bone, osteoarthritis and cartilage, skin/wound, retinal, neural, and other tissues are discussed. Finally, the advantages and limitations of natural gums are precisely described for future perspectives in tissue engineering and regenerative medicine in the concluding remarks.

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Designing tragacanth gum based sterile hydrogel by radiation method for use in drug delivery and wound dressing applications

Cited by 74 publications

References 63 publications

Physicochemical, Rheological and Structural Characteristics of Alcohol Precipitated Fraction of Gum Tragacanth

Physicochemical, Rheological and Structural Characteristics of Alcohol Precipitated Fraction of Gum Tragacanth

Antimicrobial hydrogels: promising materials for medical application

Recent Advances in Natural Gum-Based Biomaterials for Tissue Engineering and Regenerative Medicine: A Review

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