Designing the mechanical properties of peptide-based supramolecular hydrogels for biomedical applications

Liu, Ying; Qin, Meng; Cao, Yi; Wang, Wei

doi:10.1007/s11433-014-5427-z

Cited by 39 publications

(35 citation statements)

References 97 publications

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“…Low molecular weight gelators (LMWG) are molecules that self-assemble into one-dimensional fibres. [1][2][3] Under the right conditions, this self-assembly leads to the immobilisation of the solvent and hence gel formation. These materials are attracting significant interest, for example in tissue engineering and for culturing cells, [4][5][6][7] where the LMWG gel's reversibility as the cells grow and re-form their environment can be useful.…”

Section: Introductionmentioning

confidence: 99%

The effect of self-sorting and co-assembly on the mechanical properties of low molecular weight hydrogels

et al. 2014

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Self-sorting in low molecular weight hydrogels can be achieved using a pH triggered approach. We show here that this method can be used to prepare gels with different types of mechanical properties. Cooperative, disruptive or orthogonal assembled systems can be produced. Gels with interesting behaviour can be also prepared, for example self-sorted gels where delayed switch-on of gelation occurs. By careful choice of gelator, co-assembled structures can also be generated, which leads to synergistic strengthening of the mechanical properties.

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Section: Introductionmentioning

confidence: 99%

The effect of self-sorting and co-assembly on the mechanical properties of low molecular weight hydrogels

et al. 2014

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“…Inspired by nature, researchers have developed many biofunctional nanomaterials formed by the specific interactions between metal ions and peptides34567. Among them, supramolecular hydrogels89101112, especially those of peptides13141516171819202122232425, have attracted research interests due to their inherent biocompatibility, degradability, and fast responsiveness to external stimuli26272829303132. Successful examples of metal ion-induced supramolecular hydrogelations have been reported.…”

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confidence: 99%

Gd(III)-induced Supramolecular Hydrogelation with Enhanced Magnetic Resonance Performance for Enzyme Detection

Hua

et al. 2017

Sci Rep

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Here we report a supramolecular hydrogel based on Gd(III)-peptide complexes with dramatically enhanced magnetic resonance (MR) performance. The hydrogelations were formed by adding Gd(III) ion to the nanofiber dispersion of self-assembling peptides naphthalene-Gly-Phe-Phe-Tyr-Gly-Arg-Gly-Asp (Nap-GFFYGRGD) or naphthalene-Gly-Phe-Phe-Tyr-Gly-Arg-Gly-Glu (Nap-GFFYGRGE). We further showed that, by adjusting the molar ratio between Gd(III) and the corresponding peptide, the mechanical property of resulting gels could be fine-tuned. The longitudinal relaxivity (r1) of the Nap-GFFYGRGE-Gd(III) was 58.9 mM−1 S−1, which to our knowledge is the highest value for such peptide-Gd(III) complexes so far. Such an enhancement of r1 value could be applied for enzyme detection in aqueous solutions and cell lysates.

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“…Moreover, the G' of the GO/Ru(II) gel was ~0.12 MPa, which is higher than that of most supramolecular hydrogels reported so far. [37][38][39][40] The oxidation of Ru 2+ to Ru 3+ dramatically softened the hydrogel and the G' dropped almost 30 %.…”

Section: Resultsmentioning

confidence: 99%

Electroresponsive Supramolecular Graphene Oxide Hydrogels for Active Bacteria Adsorption and Removal

Xue¹,

Qin²,

Wu³

et al. 2016

ACS Appl. Mater. Interfaces

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Bacteria contamination in drinking water and medical products can cause severe health problems. However, currently available sterilization methods, mainly based on the size-exclusion mechanism, are typically slow and require the entire contaminated water to pass through the filter. Here, we present an electroresponsive hydrogel based approach for bacteria adsorption and removal. We successfully engineered a series of graphene oxide hydrogels using redox-active ruthenium complexes as noncovalent cross-linkers. The resulting hydrogels can reversibly switch their physical properties in response to the applied electric field along with the changes of oxidation states of the ruthenium ions. The hydrogels display strong bacteria adsorbing capability. A hydrogel of 1 cm(3) can adsorb a maximum of 1 × 10(8) E. coli. The adsorbed bacteria in the hydrogels can then be inactivated by a high voltage electric pulse and removed from the hydrogels subsequently. Owing to the high bacteria removal rate, reusability, and low production cost, these hydrogels represent promising candidates for the emergent sterilization of medical products or large-scale purification of drinking water.

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Designing the mechanical properties of peptide-based supramolecular hydrogels for biomedical applications

Cited by 39 publications

References 97 publications

The effect of self-sorting and co-assembly on the mechanical properties of low molecular weight hydrogels

The effect of self-sorting and co-assembly on the mechanical properties of low molecular weight hydrogels

Gd(III)-induced Supramolecular Hydrogelation with Enhanced Magnetic Resonance Performance for Enzyme Detection

Electroresponsive Supramolecular Graphene Oxide Hydrogels for Active Bacteria Adsorption and Removal

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