Designing synergistic crystallization inhibitors: Bile salt derivatives of cellulose with enhanced hydrophilicity

Poly(vinylpyridine-co-vinylpyridine N-oxide) Excipients Mediate Rapid Dissolution and Sustained Supersaturation of Posaconazole Amorphous Solid Dispersions

“…Dissolution was monitored for an additional 60 min. Aliquots were extracted at predetermined time points (5,15,30,45,60,65,90, and 120 min). Concentration was determined by UHPLC of the aqueous media as described above after passing through a polypropylene 0.45 μm syringeless filter (Cytiva) and diluting the solution in an equal amount of acetonitrile.…”

“…Hydrophilic polymers do not show pH-dependent aqueous solubility and undergo rapid dissolution under acidic conditions in the stomach. , As a result, the excipient remains in solution throughout the entire gastrointestinal system. However, neutral, hydrophilic polymers can also show preferential solvation by water over intermolecular interaction with a hydrophobic solute. , As a result, neutral excipients may be less apt to inhibit recrystallization of drug in solution compared to amphiphilic polymers such as HPMCAS, , and a growing area of research has looked to identify chemical functionalities with improved potency to prevent crystallization to encode into novel excipients. ,,− …”

Lignocellulosic–biomolecules conjugated systems: green-engineered complexes modified by covalent linkers

“…They connect biomolecules and may impart new properties to the system or enhance existing ones. [6][7][8][9][10][11][12][13][14][15][16][17][18] The primary biomolecules in bioconjugate systems include lipids, proteins, nucleic acids, and carbohydrates. [19][20][21][22][23][24] Lignocellulosic structures are notable in the carbohydrate-bioconjugate domain (Fig.…”