Designing Porous Inorganic Architectures

Melero, Juan A.; Iglesias, José; Morales, Gabriel

doi:10.1002/9783527658985.ch8

Cited by 2 publications

(1 citation statement)

References 180 publications

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“…Since additives have the ability to alter the hydrophobic-hydrophilic equilibrium, further tuning is necessary for pore expansion when applying them during synthesis. Mesitylene is utilized to increase the pore size of MSNs from 3 to 5 nm without changing the particle size, and these MSNs with larger pores are then used as a delivery system for proteins that are membrane impermeable to cancer cells [54]. To enhance pore size without altering the morphology of pre-formed particles, a freshly synthesized material is subjected to autogenic pressure during post-synthesis at temperatures between 373 K and 423 K with or without additions.…”

Section: Pore Sizementioning

confidence: 99%

Fabrication of Mesoporous Silica Nanoparticles and Its Applications in Drug Delivery

Pande,

Kothawade,

Kuskar

et al. 2023

Nanotechnology and Nanomaterials

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Mesoporous Silica Nanoparticles (MSNs) are nano-sized particles with a porous structure that offers unique advantages for drug delivery systems. The chapter begins with an introduction to MSNs, providing a definition of these nanoparticles along with a brief historical overview. The distinctive properties of MSNs, such as high surface area, tunable pore size, and excellent biocompatibility, are discussed, highlighting their potential in drug delivery applications. The synthesis methods for MSNs are presented, including template-assisted synthesis, sol-gel method, co-condensation method, and other approaches. The chapter also covers the characterization techniques used for evaluating MSNs, including morphological, structural, and chemical characterization, which are crucial for assessing their quality and functionality. The surface modification of MSNs is explored, focusing on the functionalization of surface groups, attachment of targeting ligands, and surface charge modification to enhance their interactions with specific cells or tissues. The chapter then delves into the diverse applications of MSNs, with a particular focus on drug delivery. The use of MSNs in cancer theranostics, drug delivery, imaging, biosensing, and catalysis is discussed, emphasizing their potential to revolutionize these areas. Furthermore, the toxicity and biocompatibility of MSNs are addressed, covering both in vitro and in vivo studies that evaluate their safety and efficacy.

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Section: Pore Sizementioning

confidence: 99%