Designing of membrane-active nano-antimicrobials based on cationic copolymer functionalized nanodiamond: Influence of hydrophilic segment on antimicrobial activity and selectivity

Cao, Weiwei; Wang, Xi; Li, Qiang; Peng, Xuefeng; Wang, Lina; Li, Peili; Z, Ye; Xing, Xiaodong

doi:10.1016/j.msec.2018.06.067

Cited by 12 publications

(5 citation statements)

References 41 publications

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“…As shown in Figure 3c-h, while the membrane of E. coli retained smooth after being treated with AuNC capsules, the membrane of S. aureus and MRSA became obviously fused in the presence of AuNC capsules likely due to the membrane damage, which is also consistent with the previous report of cationic antimicrobial materials. [28,39,40]…”

Section: Antibacterial Effects and Mechanism Of Aunc Capsulesmentioning

confidence: 99%

Smart Bactericidal Capsules Based on Cationic Luminescent Nanoclusters for Controllable Treatment of Drug‐Resistant Bacterial Infection

Li,

Wang,

Zhang

et al. 2024

Adv Healthcare Materials

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Effective treatment of drug‐resistant bacteria infected wound has been a longstanding challenge for healthcare systems. In particular, the development of novel strategies for controllable delivery and smart release of antimicrobial agents is greatly demanded. Herein, we report the design of biodegradable microcapsules carrying bactericidal gold nanoclusters (AuNCs) as an attractive platform for the effective treatment of drug‐resistant bacteria infective wounds. AuNC capsules are fabricated via the well‐controlled layer‐by‐layer strategy, which possess intrinsic near‐infrared fluorescence and good biocompatibility. Importantly, these AuNC capsules exhibit strong, specific antibacterial activity towards both S. aureus and methicillin‐resistant S. aureus (MRSA). Further mechanistic studies by fluorescence confocal imaging and inductively coupled plasma mass spectrometry revealed that these AuNC capsules will be degraded in the S. aureus environment rather than E. coli, which then controllably release the loaded cationic AuNCs to exert antibacterial effect. Consequently, these AuNC capsules show remarkable therapeutic effect for the MRSA infected wound on a mouse model, and intrinsic fluorescence property of AuNC capsules enables in situ visualization of wound dressings. This study suggests the great potential of microcapsule‐based platform as smart carriers of bactericidal agents for the effective treatment of drug‐resistant bacterial infection as well as other therapeutic purposes.This article is protected by copyright. All rights reserved

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Section: Antibacterial Effects and Mechanism Of Aunc Capsulesmentioning

confidence: 99%

Smart Bactericidal Capsules Based on Cationic Luminescent Nanoclusters for Controllable Treatment of Drug‐Resistant Bacterial Infection

Li,

Wang,

Zhang

et al. 2024

Adv Healthcare Materials

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“…The subsequent separation of the outer membrane from the cytoplasmic membrane caused a shift in the outer membrane permeability, allowing nanodiamonds to penetrate deeper into the envelope until the cytoplasmic membrane was destroyed, leading to leakage of bacterial contents and death. 217…”

Section: Nanobactericides Against Mdr Bacteriamentioning

confidence: 99%

Recent advances in nanoantibiotics against multidrug-resistant bacteria

Li,

Liu,

Gong

et al. 2023

Nanoscale Adv.

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“…The functionalization of ND by adsorption or covalent bond with drugs, proteins, peptides, nucleic acids, make them an emerging class of drug delivery platforms. Moreover, ND containing oxidized [18] and partially oxidized [19] surface have shown high affinity with cellular components affording antibacterial activity against several strains such as Staphylococcus aureus, Streptococcus mutans, Bacillus subtilis, and Escherichia coli [19][20][21]. It is expected that the antimicrobial activity of these ND is afforded by the hydrogen bond between the surface group of the ND and the lipids from the bacterial cell wall.…”

Section: Introductionmentioning

confidence: 99%

“…It is expected that the antimicrobial activity of these ND is afforded by the hydrogen bond between the surface group of the ND and the lipids from the bacterial cell wall. Cao et al (2018) [20] showed evidence of hydrogen bonds between the 2-hydroxyethylmethacrylate (HEMA) from surface-functionalized ND and the lipid head groups from the bacterial cell wall. Consequently, lipid membrane fluidity and selectivity were disrupted, compromising bacterial growth.…”

Section: Introductionmentioning

confidence: 99%

Diamond Nanoparticles-Porphyrin mTHPP Conjugate as Photosensitizing Platform: Cytotoxicity and Antibacterial Activity

Hurtado

Cena

et al. 2021

Nanomaterials

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Conjugation of photosensitizers (PS) with nanoparticles has been largely used as a strategy to stabilize PS in the biological medium resulting in photosensitizing nanoparticles of enhanced photoactivity. Herein, (Meso-5, 10, 15, 20-tetrakis (3-hydroxyphenyl) phorphyryn (mTHPP) was conjugated with diamond nanoparticles (ND) by covalent bond. Nanoconjugate ND-mTHPP showed suitable stability in aqueous suspension with 58 nm of hydrodynamic diameter and Zeta potential of −23 mV. The antibacterial activity of ND-mTHPP was evaluated against Escherichia coli for different incubation times (0–24 h). The optimal activity was observed after 2 h of incubation and irradiation (660 nm; 51 J/cm2) performed right after the addition of ND-mTHPP (100 μg/mL) to the bacterial suspension. The inhibitory activity was 56% whereas ampicillin at the same conditions provided only 14% of bacterial growth inhibition. SEM images showed agglomerate of ND-mTHPP adsorbed on the bacterial cell wall, suggesting that the antimicrobial activity of ND-mTHPP was afforded by inducing membrane damage. Cytotoxicity against murine embryonic fibroblast cells (MEF) was also evaluated and ND-mTHPP was shown to be noncytotoxic since viability of cells cultured for 24 h in the presence of the nanoconjugate (100 μg/mL) was 78%. Considering the enhanced antibacterial activity and the absence of cytotoxic effect, it is possible to consider the ND-mTHPP nanoconjugate as promising platform for application in antimicrobial photodynamic therapy (aPDT).

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Designing of membrane-active nano-antimicrobials based on cationic copolymer functionalized nanodiamond: Influence of hydrophilic segment on antimicrobial activity and selectivity

Cited by 12 publications

References 41 publications

Smart Bactericidal Capsules Based on Cationic Luminescent Nanoclusters for Controllable Treatment of Drug‐Resistant Bacterial Infection

Smart Bactericidal Capsules Based on Cationic Luminescent Nanoclusters for Controllable Treatment of Drug‐Resistant Bacterial Infection

Recent advances in nanoantibiotics against multidrug-resistant bacteria

Diamond Nanoparticles-Porphyrin mTHPP Conjugate as Photosensitizing Platform: Cytotoxicity and Antibacterial Activity

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