Abstract:Knowledge-based potentials are developed to investigate the differentiation of native structures from their decoy sets. This work presents the construction of two different distancedependent potential energy functions based on two basic assumptions using mathematical modeling. In the first case, according to Anfinsen's dogma, we assumed that the energy of each model structure should be more positive than the corresponding native type. In the second one, we assumed that the energy difference between the native … Show more
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