Designing of gradient scaffolds and their applications in tissue regeneration

Pattnaik, Ananya; Sanket, A. Swaroop; Pradhan, Sanghamitra; Sahoo, Rajashree; Das, Sudiptee; Pany, Swarnaprbha; Douglas, Timothy; Dandela, Rambabu; Liu, Qiang; Rajadas, Jayakumar; Pati, Sanghamitra; Smedt, Stefaan C. De; Braeckmans, Kevin; Samal, Sangram Keshari

doi:10.1016/j.biomaterials.2023.122078

Cited by 25 publications

(14 citation statements)

References 201 publications

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“…3D printing technology is a fast, efficient, and precisely controllable manufacturing technology that has been widely developed and applied in the biomedical field in recent years. − Because 3D printing technology is highly personalized, in cartilage repair, artificial cartilage matching the morphology and size of the patient’s cartilage tissue is prepared by scanning images of the patient’s cartilage defect area and then by 3D printing technology − (Figure A). These artificial cartilages can supplement the cartilage defect area and provide mechanical support and protection to promote the growth and regeneration of chondrocytes.…”

Section: Techniques Of Tissue Engineering For Cartilage Repairmentioning

confidence: 99%

Advances in Polysaccharides for Cartilage Tissue Engineering Repair: A Review

An,

Zhang,

et al. 2024

Biomacromolecules

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Cartilage repair has been a significant challenge in orthopedics that has not yet been fully resolved. Due to the absence of blood vessels and the almost cell-free nature of mature cartilage tissue, the limited ability to repair cartilage has resulted in significant socioeconomic pressures. Polysaccharide materials have recently been widely used for cartilage tissue repair due to their excellent cell loading, biocompatibility, and chemical modifiability. They also provide a suitable microenvironment for cartilage repair and regeneration. In this Review, we summarize the techniques used clinically for cartilage repair, focusing on polysaccharides, polysaccharides for cartilage repair, and the differences between these and other materials. In addition, we summarize the techniques of tissue engineering strategies for cartilage repair and provide an outlook on developing next-generation cartilage repair and regeneration materials from polysaccharides. This Review will provide theoretical guidance for developing polysaccharide-based cartilage repair and regeneration materials with clinical applications for cartilage tissue repair and regeneration.

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Section: Techniques Of Tissue Engineering For Cartilage Repairmentioning

confidence: 99%

Advances in Polysaccharides for Cartilage Tissue Engineering Repair: A Review

An,

Zhang,

et al. 2024

Biomacromolecules

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“…In some BMTs, there are gradient distributions in structural and mechanical properties, e.g., the bone-cartilage interface, which also inspires researchers for the design of mechanical and functional enhancements, especially the gradient transition from the stiff region to the soft region. 239,364,[472][473][474] Rajasekharan et al 364 reported hierarchical and heterogeneous bioinspired composites, merging molecular self-assembly with additive manufacturing. They demonstrated a combination of top-down and bottom-up approach to form a polymer-ceramic composite by macroscopically aligning the self-assembled nanostructure of polymerizable lyotropic liquid crystals by 3D printing.…”

Section: Mechanical Enhancementmentioning

confidence: 99%

Guidelines derived from biomineralized tissues for design and construction of high-performance biomimetic materials: from weak to strong

Yu,

Zhu

2024

Chem. Soc. Rev.

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“…The gradient structure of cartilage from the superficial to deep zone requires bioinks exhibiting various biomechanical and biochemical functions. Multi-material bioinks with gradient functions can be used to mimic native cartilage features, such as zonal organization and anisotropic properties [160][161][162][163]. However, bioprinting approaches developed firstly for in vitro use may not be able to translate into a viable in situ bioprinting strategy.…”

Section: Tissue Complexity Functionality and Integrationmentioning

confidence: 99%

Robotic in situ bioprinting for cartilage tissue engineering

Wang

Pereira

Peach

et al. 2023

Int. J. Extrem. Manuf.

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Articular cartilage damage caused by trauma or degenerative pathologies such as osteoarthritis can result in significant pain, mobility issues, and disability. Current surgical treatments have a limited capacity for efficacious cartilage repair, and long-term patient outcomes are not satisfying. Three-dimensional (3D) bioprinting has been used to fabricate biochemical and biophysical environments that aim to recapitulate the native microenvironment and promote tissue regeneration. However, conventional in vitro bioprinting has limitations due to the challenges associated with the fabrication and implantation of printed constructs and integration with the native cartilage tissue. In situ bioprinting is a novel strategy to directly deliver bioinks to the desired anatomical site and has the potential to overcome major shortcomings associated with conventional bioprinting. In this review, we focus on the new frontier of robotic-assisted in situ bioprinting surgical systems for cartilage regeneration. We outline existing clinical approaches and the utilisation of robotic-assisted surgical systems. Handheld and robotic-assisted in situ bioprinting techniques including minimally invasive and non-invasive approaches are defined and presented. Finally, we discuss the challenges and potential future perspectives of in situ bioprinting for cartilage applications.

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Designing of gradient scaffolds and their applications in tissue regeneration

Cited by 25 publications

References 201 publications

Advances in Polysaccharides for Cartilage Tissue Engineering Repair: A Review

Advances in Polysaccharides for Cartilage Tissue Engineering Repair: A Review

Guidelines derived from biomineralized tissues for design and construction of high-performance biomimetic materials: from weak to strong

Robotic in situ bioprinting for cartilage tissue engineering

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