Designing multimodal carbon nanotubes by covalent multi-functionalization

Dinesh, Bhimareddy; Bianco, Alberto; Ménard‐Moyon, Cécilia

doi:10.1039/c6nr06728j

Cited by 57 publications

(33 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, they can be used to perform thermal ablation [44], as well as to detect Reactive Oxygen Species (ROS) [45] or specific antigens, likewise tumor markers [46]. All these properties can be combined together to create a multifunctional tool by means of multiple functionalizations as thoroughly described in [47]. Basically, two kinds of functionalizations can be done on CNTs: covalent or non-covalent.…”

Section: Cnts and Cancermentioning

confidence: 99%

“…The next ideal step, then, is to combine all of the pros in a single technique avoiding all of the cons. For this reason, many research groups are working on multimodal CAs that can exploits all of the benefits deriving from each technique [47,97,98]. CNTs are an ideal platform for this duty due to the multiple types of functionalizations that are possible to perform on them [99].…”

Section: Cnts and Cancermentioning

confidence: 99%

See 1 more Smart Citation

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

2017

View full text Add to dashboard Cite

Despite the current progresses of modern medicine, the resistance of malignant tumors to present medical treatments points to the necessity of developing new therapeutic approaches. In recent years, numerous studies have focused their attention on the promising use of nanomaterials, like iron oxide nanowires, zinc oxide or mesoporous silica nanoparticles, for cancer and metastasis treatment with the advantage of operating directly at the bio-molecular scale. Among them, carbon nanotubes emerged as valid candidates not only for drug delivery, but also as a valuable tool in cancer imaging and physical ablation. Nevertheless, deep investigations about carbon nanotubes’ potential bio-compatibility and cytotoxicity limits should be also critically addressed. In the present review, after introducing carbon nanotubes and their promising advantages and drawbacks for fighting cancer, we want to focus on the numerous and different ways in which they can assist to reach this goal. Specifically, we report on how they can be used not only for drug delivery purposes, but also as a powerful ally to develop effective contrast agents for tumors’ medical or photodynamic imaging, to perform direct physical ablation of metastasis, as well as gene therapy.

show abstract

Section: Cnts and Cancermentioning

confidence: 99%

Section: Cnts and Cancermentioning

confidence: 99%

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

2017

View full text Add to dashboard Cite

show abstract

“…Mild oxidation followed by secondary covalent functionalization can tune the CNTs to carry a genetic load, targeting ligand, and a fluorophore for multi-modal applications. [40,41] To summarize, it was demonstrated through different investigations that f-CNTs are better suited for biological applications than pristine nanotubes.…”

Section: Derivatization Of Carbon Nanotubes For Gene Therapymentioning

confidence: 99%

“…have successively carried out 1,3‐dipolar cycloaddition reaction in the presence of protected amino acids and paraformaldehyde to form MWCNTs based drug delivery system. Mild oxidation followed by secondary covalent functionalization can tune the CNTs to carry a genetic load, targeting ligand, and a fluorophore for multi‐modal applications . To summarize, it was demonstrated through different investigations that f‐CNTs are better suited for biological applications than pristine nanotubes.…”

Section: Introductionmentioning

confidence: 99%

Derivatized Carbon Nanotubes for Gene Therapy in Mammalian and Plant Cells

et al. 2020

View full text Add to dashboard Cite

The concept of gene vectors for therapeutic applications has been known for several years, but it is far from revealing its actual potential. With the advent of hollow cylindrical carbon nanomaterials such as carbon nanotubes (CNTs), researchers have invented several new tools to deliver genes at the required site of action in mammalian and plant cells. The ease of diversified functionalization has allowed CNTs to be by far the most adaptable non‐viral vector for gene therapy. This Minireview addresses the dexterity with which CNTs undergo surface modifications and their applications as a potent vector in gene therapy of humans and plants. Specifically, we will discuss the new tools that scientific communities have invented to achieve gene therapy using plasmid DNA, RNA silencing, suicide gene therapy, and plant genetic engineering. Additionally, we will shed some light on the mechanism of gene transportation using carbon nanotubes in cancer cells and plants.

show abstract

“…14 This scheme has been widely employed not only for altering the SWCNT electronic structure but also for grafting functional moieties with multiple anchoring possibilities. 15 More recently, the diazonium chemistry of SWCNTs has been used for the creation of bright, fluorescent quantum defects. Changes in SWCNT photoluminescence through covalent sidewall functionalization have proven enormously versatile.…”

Section: Introductionmentioning

confidence: 99%