Designing General Anesthetics That Have a Better Safety Profile

Abstract

General anesthetics constitute some of the most important and widely-used therapeutic drugs in the pharmacotherapeutic armamentarium. They are routinely used effectively and with adequate precaution-safety throughout the world for a multitude of clinical applications, predominantly as adjunctive agents for surgical procedures. Nevertheless, they have potential adverse effects (such as a drop in blood pressure and the inhibition of steroid production), particularly in vulnerable populations such as the very young and the frail elderly. It would be desirable therefore to have alternative agents that are just as efficacious, but have a better safety profile in a broader spectrum of patients. Toward this end, an anesthetic based on a unique chemical core (viz., an N-arylpyrrole derivative) has been reported in preclinical models to produce anesthetic effects without hemodynamic suppression. This lead could pave the way for new general anesthetics that are safer and easier to use.

Relationship between Artificial Intelligence-Based General Anesthetics and Postoperative Cognitive Dysfunction

“…Unknown data can be easily obtained through the block method, and the sum of squares of the difference between the requested data and the actual data is the smallest. The least-squares method can also be used to place curves [ 16 ]. The basic principles are as follows.…”