Designing functionalized nanodiamonds with hyaluronic acid–phospholipid conjugates for enhanced cancer cell targeting and fluorescence imaging capabilities

Sturari, Sofia; Andreana, Ilaria; Aprà, Pietro; Bincoletto, Valeria; Kopecka, Joanna; Mino, Lorenzo; Zurletti, Beatrice; Stella, Barbara; Riganti, Chiara; Arpicco, Silvia; Picollo, Federico

doi:10.1039/d4nr00932k

Nanoscale

2024

DOI: 10.1039/d4nr00932k

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Designing functionalized nanodiamonds with hyaluronic acid–phospholipid conjugates for enhanced cancer cell targeting and fluorescence imaging capabilities

Sofia Sturari,

Ilaria Andreana,

Pietro Aprà

et al.

Abstract: Nanomedicine aims to develop smart approaches for treating cancer and other diseases to improve patient survival and quality of life. Novel nanoparticles as nanodiamonds (NDs) represent promising candidates to overcome...

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Creation, Control, and Modeling of NV Centers in Nanodiamonds

Aprà,

Amine,

Britel

et al. 2024

Adv Funct Materials

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Sensing based on Nitrogen‐Vacancy (NV) centers in nanodiamonds (NDs) represents a potentially groundbreaking technology with broad applications. Nevertheless, the optimization of their quantum‐optical properties is still a challenging issue. The present work aims at enhancing and controlling NV centers optical properties in NDs by combining their surface chemistry tuning and proton beam irradiation. Systematic thermal oxidations are carried out to study the evolution of surface chemical groups (IR spectroscopy), as well as their influence on optical properties (photoluminescence spectroscopy, PL decay measurements). Proton irradiation is performed by exploring a wide range of fluences (1014 – 1017 cm−2) in order to precisely control the amount of NV centers, thus defining the conditions that maximize their creation and emission intensity. In addition, NV centers charge state control is achieved by assessing NV−/NV0 ratio upon different surface termination tuning and NV centers amount. Finally, a novel predictive mathematical model is developed, allowing for the evaluation of the efficiencies of the formation of both NV− and NV0. Although the model is tested in the specific case study with proton irradiated NDs, it offers a broad applicability, thus representing a key landmark in the prediction of the outcome of ion‐beam‐based color centers generation in diamond.

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Creation, Control, and Modeling of NV Centers in Nanodiamonds

Aprà,

Amine,

Britel

et al. 2024

Adv Funct Materials

Self Cite

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Designing functionalized nanodiamonds with hyaluronic acid–phospholipid conjugates for enhanced cancer cell targeting and fluorescence imaging capabilities

Abstract: Nanomedicine aims to develop smart approaches for treating cancer and other diseases to improve patient survival and quality of life. Novel nanoparticles as nanodiamonds (NDs) represent promising candidates to overcome...

Cited by 1 publication

References 88 publications

Creation, Control, and Modeling of NV Centers in Nanodiamonds

Creation, Control, and Modeling of NV Centers in Nanodiamonds

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