Designing dental composites with bioactive and bactericidal properties

Chatzistavrou, Xanthippi; Velamakanni, S.S.; DiRenzo, Kyle; Lefkelidou, Anna; Fenno, J. Christopher; Kasuga, Toshihiro; Boccaccını, Aldo R.; Papagerakis, Pétros

doi:10.1016/j.msec.2015.03.062

Cited by 64 publications

(51 citation statements)

References 31 publications

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“…Ag-BGCOMP showed only 5% less depth of cure than the control, which is not clinically significant if the control group cured for more than 80%. Moreover the non-clinically significant difference was also anticipated based on our previous work on the bond strength values for 5 and 15 wt % Ag-BG [18]. Non-significant differences to the control were found for these values as well, which is expected to also be the case for the 10 wt % of Ag-BG.…”

Section: Discussionsupporting

confidence: 56%

“…The concentration of 10 wt % Ag-BG was chosen based on the results of our previous work with 5 and 15 wt % Ag-BG [18]. The specific concentration is expected to present optimum bactericidal and mechanical properties.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, a path for microorganisms is created and, subsequently, failure of the restoration may occur if it takes place at an exposed margin [16,17]. The development of composites with bioactive behavior being capable of forming an apatite layer on their surface could provide the required conditions, which may improve its bond with the dentinal wall [18]. Moreover, filler content in composites is one of the factors affecting the amount of polymerization shrinkage [19].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, a new one-step self-adhering flowable resin composite (modified-composite) was developed incorporating an Ag-doped bioactive glass (Ag-BG). Ag-BG was previously evaluated for its effective antimicrobial activity, the potential to form an apatite phase and the total bond strength [18,20,21]. The aim of this study was to characterize key mechanical, physical and bactericidal properties of the newly developed Ag-BG flowable composite (Ag-BGCOMP).…”

Section: Introductionmentioning

confidence: 99%

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Physical Properties of an Ag-Doped Bioactive Flowable Composite Resin

et al. 2015

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The aim of this work was to study the physical and antibacterial properties of a flowable resin composite incorporating a sol-gel derived silver doped bioactive glass (Ag-BGCOMP). The depth of the cure was calculated by measuring the surface micro-hardness for the top and bottom surfaces. The volumetric polymerization shrinkage was measured by recording the linear shrinkage as change in length, while the biaxial flexural strength was studied measuring the load at failure. The antibacterial properties of the samples were tested against Streptococcus mutans (S. mutans) and Lactobacillus casei (L. casei). The measured values were slightly decreased for all tested physical properties compared to those of control group (flowable resin composite without Ag-BG), however enhanced bacteria inhibition was observed for Ag-BGCOMP. Ag-BGCOMP could find an application in low stress-bearing areas as well as in small cavity preparations to decrease secondary caries. This work provides a good foundation for future studies on evaluating the effects of Ag-BG addition into packable composites for applications in larger cavity preparations where enhanced mechanical properties are needed.

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Section: Discussionsupporting

confidence: 56%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Physical Properties of an Ag-Doped Bioactive Flowable Composite Resin

et al. 2015

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“…Recent studies have reported technological improvements in composite resin. Of particular interest are antibacterial additives that might reduce secondary caries and biofilms and enhance remineralization of teeth (29)(30)(31). Thus, material-induced reactions should be expected when margins beyond the CEJ are required.…”

Section: Discussionmentioning

confidence: 99%

Biological evaluation of subgingivally placed direct resin composite materials

et al. 2018

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In addition, high-performance liquid chromatography (HPLC) was used to determine release of resin monomers from RBCs after 1 h, 1 day, and 7 days. As compared with tissue culture plastics (the control), cellular adhesion was significantly lower (P < 0.001) for human gingival fibroblasts and osteoblasts. Only minor, nonsignificant differences between individual RBCs were identified. HPLC analyses identified the release of three bifunctional methacrylates bisphenol A glycerolate dimethacrylate, triethylene glycol dimethacrylate, and diurethane dimethacrylate from RBCs and showed that monomer release increased between 1 h and 1 day but remained low. The present findings suggest that surface adhesion in the subgingival area is limited for the tested RBCs. Although residual monomer release was low for all tested RBCs, it might be sufficient to adversely affect cell adhesion.

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