Designing cytochrome P450 enzymes for use in cancer gene therapy
Saskya E. Carrera-Pacheco,
Alexander Mueller,
Juan A. Puente-Pineda
et al.
Abstract:Cancer is a significant global socioeconomic burden, as millions of new cases and deaths occur annually. In 2020, almost 10 million cancer deaths were recorded worldwide. Advancements in cancer gene therapy have revolutionized the landscape of cancer treatment. An approach with promising potential for cancer gene therapy is introducing genes to cancer cells that encode for chemotherapy prodrug metabolizing enzymes, such as Cytochrome P450 (CYP) enzymes, which can contribute to the effective elimination of canc… Show more
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