The chapter will start with an overview of today´s challenges of engineering education. DOE can be very effective for solving problems in view of the new pedagogical challenges in engineering education. The chapter reviews the progress of DOE in engineering teaching and learning for problem solving and for product/process optimization with focus on engineering education in this new millennium. The goal is to identify the main engineering areas accounting for the use of statistical experimental design in engineering education as well as the main teaching/learning strategies and the combination of other tools used to support the use of DOE in engineering education. The main contribution will be to bring up ideas from studies of DOE in teaching/learning engineering environments to better understand the deficit of utilization of such type of approaches in academic projects/experiments despite the common utilization of DOE in statistics and quality literature.