As digital twins are gaining importance in various industries, research on their impact, use cases, and implementation in the field of construction is accelerating. In this study, we examine the impact of digital twins on building safety and security throughout their lifecycle, utilizing two state-of-the-art use cases for fire and anomaly detection. The solution employs advanced sensors, 3D visualizations for detecting safety and security threats, and data analysis to predict potential future threats. Using the data that was collected over a seventeen-month period, we present an implementation architecture for safety and security digital twins in buildings, explore the benefits and shortcomings of such a system, and discuss the learnings applicable to different lifecycle stages of a building. This paper contributes to the creation and study of a digital twin for fire safety, analyzing its performance using two real-world use cases and reporting the implementation results. Additionally, we extrapolate the learnings from the use phase of a facility to other lifecycle phases of buildings and facilities.INDEX TERMS Digital twin, building lifecycle management, fire safety, safety and security in buildings.