Designing and computational analyzing of chimeric long-lasting GLP-1 receptor agonists for type 2 diabetes
Maryam Ehsasatvatan,
Bahram Baghban Kohnehrouz
Abstract:Glucagon-like peptide-1 (GLP-1) is an intestinally derived incretin that plays a vital role in engineering the biological circuit involved in treating type 2 diabetes. Exceedingly short half-life (1–2 min) of GLP-1 limits its therapeutic applicability, and the implication of its new variants is under question. Since albumin-binding DARPin as a mimetic molecule has been reported to increase the serum half-life of therapeutic compounds, the interaction of new variants of GLP-1 in fusion with DARPin needs to be e… Show more
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