Designing an ultra‐short antibacterial peptide with potent activity against Mupirocin‐resistant MRSA

Abstract

Staphylococcus aureus is the pathogen responsible for the majority of human skin infections. In particular, the methicillin-resistant variety, MRSA, has become a global clinical concern. The extensive use of mupirocin, the first-line topical antibacterial drug of choice, has led to the emergence of mupirocin-resistant MRSA globally, resulting in the urgent need for a replacement. Antimicrobial peptides are deemed plausible candidates. Herein, we describe a structure-activity relationship approach in the design of an ultra-short peptide with potent anti-MRSA activity with a rapid, bactericidal mode of action. Coupled to a low cytotoxic activity, we believe our lead compound can be developed into a topical antibacterial agent to replace mupirocin as the first-line drug for treating MRSA skin infections.

Poly-tetrahydropyrimidine Antibacterial Hydrogel with Injectability and Self-Healing Ability for Curing the Purulent Subcutaneous Infection

“…Pyrimidines and their derivatives played an important role in the bioactive field. , As an important heterocyclic molecule, tetrahydropyrimidine has recently attracted interest due to its pharmacological activities such as antiviral and antibacterial activities. , Compared to the small-molecule structure of the antibiotic, antibacterial polymers such as antibacterial peptides and cationic polymers exhibited a much lower rate in driving multidrug resistance (MDR). , From this standpoint, multifunctional polymers exhibiting unlimited potential are a new generation of antimicrobial agents. Poly-tetrahydropyrimidine (PTHP), due to its efficient “one-pot” synthesis and aggregation-induced emission (AIE) properties, results in the neglect of its excellent biocompatibility and antibacterial properties .…”

“…32,33 Compared to the small-molecule structure of the antibiotic, antibacterial polymers such as antibacterial peptides and cationic polymers exhibited a much lower rate in driving multidrug resistance (MDR). 34,35 From this standpoint, multifunctional polymers exhibiting unlimited potential are a new generation of antimicrobial agents. Poly-tetrahydropyrimidine (PTHP), due to its efficient "one-pot" synthesis and aggregation-induced emission (AIE) properties, results in the neglect of its excellent biocompatibility and antibacterial properties.…”

Fabrication and Characterization of Composite Meshes Loaded with Antimicrobial Peptides

“…AMPs are deemed to be a new promising class of antibacterial agents because of their broad spectrum and rapid bactericidal performances. 28,29 The AMP we used in this study is a synthetic cationic peptide produced and purified in our lab. In order to load the AMP into meshes effectively, electrospinning poly(ε-caprolactone) (PCL) film and GG solution were selected.…”

“…This study describes a new composite mesh with antibacterial property by loading antimicrobial peptides (AMPs) in gellan gum (GG) and a large-pore mesh knitted with PP monofilament used as a matrix. AMPs are deemed to be a new promising class of antibacterial agents because of their broad spectrum and rapid bactericidal performances. , The AMP we used in this study is a synthetic cationic peptide produced and purified in our lab. In order to load the AMP into meshes effectively, electrospinning poly­(ε-caprolactone) (PCL) film and GG solution were selected.…”