Designing an effective dissolution test for bilayer tablets tailored for optimal melatonin release in sleep disorder management
Rebecca Bassetto,
Emanuele Amadio,
Francesco Ciampanelli
et al.
Abstract:This project aims to investigate the release performance of bilayer tablet (BL-Tablet) designed with both fast and slow-release technology, targeting sleep disorders. The tablet incorporates Melatonin, extracts of Eschscholzia californica and Melissa officinalis. In order to validate the effectiveness of the extended-release profile, an advanced dissolution test was herein proposed. This new method utilizes biorelevant intestinal fluid media and incorporates a stomach-to-intestine fluid changing (SIFC) system.… Show more
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