The current fossil-based economy is moving towards a more bio-based economy. To enable this transition, many different processes for biorefi nery are being developed. Small-scale biorefi nery processes can be benefi cial, not only socially and ecologically, but also economically. The main motivation for smallscale biorefi nery is local re-use of materials, like water, minerals, organic matter, CO 2 , and heat. This minimizes costs for recycling and transport. A smart and integrated process design can beat the advantages of economy of scale applied in large-scale processes. Examples of two fully operational small-scale systems that produce ethanol and starch are given to illustrate our theory. Specifi c design rules for small-scale biorefi neries are defi ned. The focus in design for small-scale processes should be on minimizing capital costs.Moreover, it is shown that separation of relatively simple pre-processing at small decentralized and more capital-intensive processing at large centralized factories, respectively, is advantageous. Integration with a biogas and combined heat and power (CHP) unit will furthermore allow usage of residual material to produce energy needed in the rest of the process.