Designing a gas foamed scaffold for keratoprosthesis

T-style keratoprosthesis based on surface-modified poly (2-hydroxyethyl methacrylate) hydrogel for cornea repairs

“…8 shows that visible light transmittance through the PHEMA Kpro optic column in the wavelength ranging from 500 to 700 nm is more than 90%, which is consistent with similar measurements reported by Gulsen and Chauhan [43] and approximates that of the natural cornea [44]. The PHEMA Kpro optic column modified with PEG had a high visible light transmittance (~82%) in the visible light wavelength range, although it was slightly less than that of the unmodified PHEMA optic column (~90%) [13]. The modification process did not cause any obvious destruction on the smooth surface of the optic column, which was in agreement with the SEM results (see Section 3.4).…”

Composite core-and-skirt collagen hydrogels with differential degradation for corneal therapeutic applications

“…Construction of inert prostheses with regenerative capacity therefore includes many technically demanding steps [9,11,12]. Alternatively, composites presented here are composed of a safe and well-characterized medical-grade porcine collagen not requiring surface modification.…”

3D Biofabrication Strategies for Tissue Engineering and Regenerative Medicine

“…Gas foaming is a biofabrication technique in which a polymeric scaffold is saturated with a foaming agent such as carbon dioxide (84), nitrogen (85), or water (86) at high pressures. The pressure of the foaming agent is decreased, which leads to a decrease in the solubility of the gas in the polymer.…”