Designer emulsions using microfluidics

Shah, Rhutesh K.; Shum, Ho Cheung; Rowat, Amy C.; Lee, Daeyeon; Agresti, Jeremy J.; Utada, Andrew S.; Chu, Liang‐Yin; Kim, Jinwoong; Fernández‐Nieves, Alberto; Martínez, Carlos; Weitz, David A.

doi:10.1016/s1369-7021(08)70053-1

Cited by 656 publications

(513 citation statements)

References 52 publications

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“…Microfluidic production of double emulsions is preferable to bulk preparation methods 43,44 because it produces monodisperse emulsion droplets and is a very wellcontrolled process allowing the number of encapsulated droplets to be precisely defined 45 . The production of double emulsions in microfluidic devices is a challenging task as it requires synchronization of the droplet formation frequencies and very specific channel wettability; oil droplet formation can only be realized at a hydrophilic flow-focusing junction, whereas the aqueous droplets can only form at a hydrophobic junction.…”

Section: Generation Of O/w/o and W/o/w Double Emulsionsmentioning

confidence: 99%

Hydrophilic surface modification of PDMS for droplet microfluidics using a simple, quick, and robust method via PVA deposition

et al. 2017

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Polydimethylsiloxane (PDMS) is a dominant material in the fabrication of microfluidic devices to generate water-in-oil droplets, particularly lipid-stabilized droplets, because of its highly hydrophobic nature. However, its key property of hydrophobicity has hindered its use in the microfluidic generation of oil-in-water droplets, which requires channels to have hydrophilic surface properties. In this article, we developed, optimized, and characterized a method to produce PDMS with a hydrophilic surface via the deposition of polyvinyl alcohol following plasma treatment and demonstrated its suitability for droplet generation. The proposed method is simple, quick, effective, and low cost and is versatile with respect to surfactants, with droplets being successfully generated using both anionic surfactants and more biologically relevant phospholipids. This method also allows the device to be selectively patterned with both hydrophilic and hydrophobic regions, leading to the generation of double emulsions and inverted double emulsions.

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Section: Generation Of O/w/o and W/o/w Double Emulsionsmentioning

confidence: 99%

Hydrophilic surface modification of PDMS for droplet microfluidics using a simple, quick, and robust method via PVA deposition

et al. 2017

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“…While Weitz-type glass capillary based devices are inherently hydrophilic, Whitesides-type PDMS devices are hydrophobic and generally treated prior to use [212], with a plasma [213] for instance, to change its wettability. In the case of W/O emulsions, the glass capillary device needs to be adapted which can be easily done via chemical treatment by silanes [214]. In terms of channel dimensions, the rule of thumb is 'the smaller the better', provided that the wettability is adjusted.…”

Section: Droplet Formation In Microfluidic Channelsmentioning

confidence: 99%

Porous polymer particles—A comprehensive guide to synthesis, characterization, functionalization and applications

Gökmen

Prez

2012

Progress in Polymer Science

440

307

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“…The chance of fouling inside the microreactor can be inhibited by isolating solid nanoparticle products to keep them away from inner wall of the channel. [37,234] Frenz et al [232] demonstrated a synchronized production of droplet pairs that are stabilized by surfactant for the synthesis of iron oxide magnetic nanoparticles by coprecipitation ferrous and ferric salts in a presence of a base. The microfluidic device was designed to pair perfect one-by-one droplet by the use of two hydrodynamically coupled nozzles and surface-modified channels (Figure 18a,b).…”

Section: Droplet-based Microreactorsmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

186

169

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Designer emulsions using microfluidics

Cited by 656 publications

References 52 publications

Hydrophilic surface modification of PDMS for droplet microfluidics using a simple, quick, and robust method via PVA deposition

Hydrophilic surface modification of PDMS for droplet microfluidics using a simple, quick, and robust method via PVA deposition

Porous polymer particles—A comprehensive guide to synthesis, characterization, functionalization and applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

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