Designer DNA Strand Displacement Reaction toward Controlled Release of Cargos
Chih-Hsiang Hu,
Remi Veneziano
Abstract:Dynamic DNA nanotechnology systems are used to design DNA logic circuits, signal amplification mechanisms for biosensing, and smart release system that could potentially be used in several biomedical applications. The toehold-mediated strand displacement reaction (TMSDR) is one of the main methods for designing DNA-based biomolecular logic circuits. However, the reaction behaviour such as the displacement rate and the quantity of strand released are difficult to control and often requires chemically modified s… Show more
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