Designed synthesis and surface engineering strategies of magnetic iron oxide nanoparticles for biomedical applications

Abstract

Iron oxide nanoparticles (NPs) hold great promise for future biomedical applications because of their magnetic properties as well as other intrinsic properties such as low toxicity, colloidal stability, and surface engineering capability. Numerous related studies on iron oxide NPs have been conducted. Recent progress in nanochemistry has enabled fine control over the size, crystallinity, uniformity, and surface properties of iron oxide NPs. This review examines various synthetic approaches and surface engineering strategies for preparing naked and functional iron oxide NPs with different physicochemical properties. Growing interest in designed and surface-engineered iron oxide NPs with multifunctionalities was explored in in vitro/in vivo biomedical applications, focusing on their combined roles in bioseparation, as a biosensor, targeted-drug delivery, MR contrast agents, and magnetic fluid hyperthermia. This review outlines the limitations of extant surface engineering strategies and several developing strategies that may overcome these limitations. This study also details the promising future directions of this active research field.

Application of nanodiagnostics in point-of-care tests for infectious diseases

“…47 Magnetic nanoparticles have been successfully applied in many biomedical applications, such as bioimaging, cancer therapy, and nanodiagnostics. [48][49][50][51][52] This diagnosis is based on the enhanced separation and detection of aligned magnetic nanoparticles bonded with targeting agents under an applied magnetic field. 9 As commonly used magnetic nanoparticles, iron oxide nanoparticles, composed of magnetite or maghemite cores, have been used as contrast agents for magnetic resonance imaging.…”

Монодисперсные Частицы Со Структурой Ядро--Оболочка Из Магнетита И Функционализированного Люминофором Мезопористого Кремнезема

“…DOI: 10.21883/PJTF.2017. 15.44872.16823 В настоящее время магнитные наночастицы вызывают все больший интерес у исследователей благодаря возможности их применения в био-медицине, например в магнитной гипертермии, магнитно-резонансной томографии (МРТ), адресной доставке лекарств [1][2][3] [4][5][6]. Особое внимание в последние годы уделяют маленьким частицам (размером в единицы-десятки нанометров), которые являются однодоменными.…”

Smart multifunctional nanoagents for in situ monitoring of small molecules with a switchable affinity towards biomedical targets

“…For example, nanoparticles can be sensors (Howes et al 2014), actuators (Govorov et al 2006), vectors (Cheng et al 2008) and markers (Lin et al 2005). Besides, their properties and performance can be easily adjusted by changing composition, coating or functional molecules immobilized on their surface (Wu et al 2016). While their therapeutic applications only start to develop, nanoparticles are already widely used for biosensing in various areas ranging from food safety to in vitro diagnostics (Peng et al 2015;Rocha-Santos 2014).…”