Designed Fabrication of Multifunctional Magnetic Gold Nanoshells and Their Application to Magnetic Resonance Imaging and Photothermal Therapy

Kim, Jaeyun; Park, Sung Jin; Lee, Ji Eun; Jin, Seung Min; Lee, Jun Young; Lee, In Su; Yang, Inho; Kim, Jun-Sung; Kim, Seong Keun; Cho, Myung‐Haing; Hyeon, Taeghwan

doi:10.1002/ange.200602471

Cited by 186 publications

(104 citation statements)

References 54 publications

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“…Biomedical applications of such artificially engineered magnetic nanoparticles are promising since they can be useful as next-generation probes and vectors, which can significantly advance the current clinical diagnostic and therapeutic methods. 7,[19][20][21][22][23][24][25][26][27][28][29][30][31][32] Upon conjugation with target-specific biomolecules, these magnetic nanoparticles can travel in human bodies via blood or lymphatic vessels and recognize desired biological targets and report their positions. Alternatively, by focusing an external magnetic field to the target region, magnetic nanoparticles can direct therapeutic agents to a localized target.…”

Section: Figurementioning

confidence: 99%

Nanoscaling Laws of Magnetic Nanoparticles and Their Applicabilities in Biomedical Sciences

2008

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Magnetic nanoparticles, which exhibit a variety of unique magnetic phenomena that are drastically different from those of their bulk counterparts, are garnering significant interest since these properties can be advantageous for utilization in a variety of applications ranging from storage media for magnetic memory devices to probes and vectors in the biomedical sciences. In this Account, we discuss the nanoscaling laws of magnetic nanoparticles including metals, metal ferrites, and metal alloys, while focusing on their size, shape, and composition effects. Their fundamental magnetic properties such as blocking temperature (T b ), spin life time (τ), coercivity (H c ), and susceptibility ( ) are strongly influenced by the nanoscaling laws, and as a result, these scaling relationships can be leveraged to control magnetism from the ferromagnetic to the superparamagnetic regimes. At the same time, they can be used in order to tune magnetic values including H c , , and remanence (M r ). For example, life time of magnetic spin is directly related to the magnetic anisotropy energy (K u V ) and also the size and volume of nanoparticles. The blocking temperature (T b ) changes from room temperature to 10 K as the size of cobalt nanoparticles is reduced from 13 to 2 nm. Similarly, H c is highly susceptible to the anisotropy of nanoparticles, while saturation magnetization is directly related to the canting effects of the disordered surface magnetic spins and follows a linear relationship upon plotting of m s 1/3 vs r -1. Therefore, the nanoscaling laws of magnetic nanoparticles are important not only for understanding the behavior of existing materials but also for developing novel nanomaterials with superior properties.Since magnetic nanoparticles can be easily conjugated with biologically important constituents such as DNA, peptides, and antibodies, it is possible to construct versatile nano-bio hybrid particles, which simultaneously possess magnetic and biological functions for biomedical diagnostics and therapeutics. As demonstrated in this Account, nanoscaling laws for magnetic components are found to be critical to the design of optimized magnetic characteristics of hybrid nanoparticles and their enhanced applicability in the biomedical sciences including their utilizations as contrast enhancement agents for magnetic resonance imaging (MRI), ferromagnetic components for nano-bio hybrid structures, and translational vectors for magnetophoretic sensing of biological species. In particular, systematic modulation of saturation magnetization of nanoparticle probes is important to maximize MR contrast effects and magnetic separation of biological targets.

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Section: Figurementioning

confidence: 99%

Nanoscaling Laws of Magnetic Nanoparticles and Their Applicabilities in Biomedical Sciences

2008

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“…The absorption peak of Au nanorods [11,25,26,38] may be tuned from 550 nm up to 1µm by altering its aspect ratio. Another way is to utilize Au nanoshells with a high refractive index of core material (e.g., Si or SiO 2 ) [23,[39][40][41][42][43]. The absorption peak of Au nanoshells is easily tuned to biological transparency window by varying both core radius and shell thickness.…”

Section: Introductionmentioning

confidence: 99%

New ideally absorbing Au plasmonic nanostructures for biomedical applications

Zakomirnyi

Rasskazov

Карпов

et al. 2017

Journal of Quantitative Spectroscopy and Radiative Transfer

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In this paper a new set of plasmonic nanostructures operating at the conditions of an ideal absorption [1] was proposed for novel biomedical applications. We consider spherical x/Au nanoshells and Au/x/Au nanomatryoshkas, where 'x' changes from conventional Si and SiO 2 to alternative plasmonic materials [2], such as zinc oxide doped with aluminum, gallium and indium tin oxide. The absorption peak of proposed nanostructures lies within 700-1100nm wavelength region and corresponds to the maximal optical transparency of hemoglobin and melanin as well as to the radiation frequency of available pulsed medical lasers. It was shown that the ideal absorption takes place in a given wavelength region for Au coatings with thickness less than 12nm. In this case finite quantum size effects for metallic nanoshells play significant role. The mathematical model for the search of the ideal absorption conditions was modified by taking into account the finite quantum size effects.

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“…Apart from Au-'Si' composites, the preparation of multifunctional Au-'Si'-Fe composite spheres has also received more attention [30][31][32][33][34][35][36][37]. Au-'Si'-Fe composite spheres are useful as magnetic drug delivery vectors or catalyst supports [32].…”

Section: Introductionmentioning

confidence: 99%

“…Au-'Si'-Fe composite spheres are useful as magnetic drug delivery vectors or catalyst supports [32]. These type of structures can be built layer-by-layer (LBL) [33][34][35][36], or by covering the 'Si' surface with a single layer made up of Au and iron oxide [30,31]. The LBL approach involves coating the iron oxide-based magnetic NPs with a layer of either 'Si', followed by an over coat of Au NPs [34][35][36], or Au-'Si' core-shell NPs [33].…”

Section: Introductionmentioning

confidence: 99%

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One-step deposition of Au nanoparticles onto chemically modified ceramic hollow spheres via self-assembly

Begum

Jones

Lynch

et al. 2012

Journal of Experimental Nanoscience

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A concentrated citrate-stabilised Au nanoparticle (NP) colloid has been prepared using a modified Frens procedure, and characterised using transmission electron microscopy (TEM) and UV-Vis absorption spectroscopy. The average diameter determined from TEM images of concentrated Au NPs (16.57 AE 0.65 nm) is similar to the diameter reported by Frens (16 nm). The surface plasmon band of the concentrated Au NPs UV-Vis spectrum has a max at 522 nm. Bare silica ('Si') and iron-'Si' hollow microsphere surfaces have been functionalised with amino groups using the surfactant 3-aminopropyltrimethoxysilane (APTMS). The Au NPs have been assembled onto the APTMS-treated hollow spheres by dispersing a colloid of Au NPs into a suspension of hollow spheres at pH 4.5 (2 h). The volume ratio of Au NPs: hollow spheres was adjusted until maximum deposition could be achieved in a single step. TEM micrographs of ultrathin (80-100 nm) ultramicrotome sections through the Au NP-coated hollow spheres reveal that a single layer of Au NPs is mainly distributed on (1) the external side of the shell wall for 'Si' and (2) both sides of the shell wall for iron-'Si'. UV-Vis absorption spectra of the Au NP-coated hollow spheres show that the surface plasmon band shifts (524-613 nm) and broadens as the density of Au NPs is increased on the shell surface.

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Designed Fabrication of Multifunctional Magnetic Gold Nanoshells and Their Application to Magnetic Resonance Imaging and Photothermal Therapy

Cited by 186 publications

References 54 publications

Nanoscaling Laws of Magnetic Nanoparticles and Their Applicabilities in Biomedical Sciences

Nanoscaling Laws of Magnetic Nanoparticles and Their Applicabilities in Biomedical Sciences

New ideally absorbing Au plasmonic nanostructures for biomedical applications

One-step deposition of Au nanoparticles onto chemically modified ceramic hollow spheres via self-assembly

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