Designed Fabrication of Multifunctional Magnetic Gold Nanoshells and Their Application to Magnetic Resonance Imaging and Photothermal Therapy

Kim, Jaeyun; Park, Sung Jin; Lee, Ji Eun; Jin, Seung Min; Lee, Jun Young; Lee, In Su; Yang, Inho; Kim, Jun-Sung; Kim, Seong Keun; Cho, Myung‐Haing; Hyeon, Taeghwan

doi:10.1002/anie.200602471

Cited by 484 publications

(186 citation statements)

References 54 publications

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“…Fe 3 O 4 magnetite microspheres were synthesized via a solvothermal reaction in which FeCl 3 and CH 3 COONa were added in ethylene glycol with stirring, followed by adding HOCH 2 CH 2 OH into the mixture. The detailed experimental procedure can be found in former studies.…”

Section: Methodsmentioning

confidence: 99%

“…[1][2][3][4][5][6] Among a large variety of magnetic nanocomposites comprised of different constitutes, combination of ferromagnetic materials with noble metals in an arrangement of core-shell configuration is of particular interest because of the resulting simultaneous optical and magnetic response as well as their flexible control through an application of external magnetic fields. [7][8][9][10][11][12][13][14][15][16][17][18] These bifunctional structures have demonstrated great potential in biosensing and bioimaging applications.…”

Section: Introductionmentioning

confidence: 99%

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Maximizing surface-enhanced Raman scattering sensitivity of surfactant-free Ag-Fe3O4 nanocomposites through optimization of silver nanoparticle density and magnetic self-assembly

Bao

Lei

2013

Journal of Applied Physics

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Magnetic composite nanomaterials consisting of more than two functional constituents have been attracting much research interests due to the realization of multiple functionalities in a single entity. In particular, integration of ferromagnetic oxides and noble metal nanoparticles (NPs) in composites results in simultaneous magnetic activity and optical response where the optical property of the whole system could be modulated by application of an external magnetic field. In this work, we prepared Ag NPs-coated Fe 3 O 4 microspheres as a novel surfactant-free surfaceenhanced Raman scattering (SERS) substrate through a solid-phase thermal decomposition reaction. The SERS sensitivity of the fabricated nanocomposites is maximized by adjusting the size and density of Ag NPs supported on the Fe 3 O 4 microspheres and further increased by magneticfield-directed self-assembly of the composite substrates, with both effects attributed to the efficient generation of plasmonic near-field "hot" spots. At the optimal conditions, the prepared substrate is capable of detecting rhodamine 6G molecules at a concentration down to 10 À12 M, thus demonstrating the great potential of using bifunctional nanocomposites as an excellent candidate for ultra-high sensitive Raman spectroscopy and biosensors. We also reveal the underlying mechanisms responsible for the observed SERS enhancements through full-wave numerical simulations. V C 2013 AIP Publishing LLC. [http://dx

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maximizing surface-enhanced Raman scattering sensitivity of surfactant-free Ag-Fe3O4 nanocomposites through optimization of silver nanoparticle density and magnetic self-assembly

Bao

Lei

2013

Journal of Applied Physics

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“…[1][2][3][4][5][6][7][8][9] To date, several types of hybrid nanosystems containing multiple different types of nanoparticles have been developed that allow multimodal imaging. For example, formulations containing quantum dots (QD) and magnetic iron oxide nanoparticles (MN) provide a means to perform simultaneous fluorescent optical imaging and magnetic resonance imaging (MRI).…”

mentioning

confidence: 99%

Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery

et al. 2008

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Keywords biological imaging; cancer; drug delivery; magnetic nanoparticles; micelle; quantum dots Multifunctional nanoparticles have the potential to integrate therapeutic and diagnostic functions into a single nanodevice. [1][2][3][4][5][6][7][8][9] To date, several types of hybrid nanosystems containing multiple different types of nanoparticles have been developed that allow multimodal imaging. For example, formulations containing quantum dots (QD) and magnetic iron oxide nanoparticles (MN) provide a means to perform simultaneous fluorescent optical imaging and magnetic resonance imaging (MRI). [10][11][12][13][14][15] While these nanocomposites have been used for in vitro magnetic cell separation and in vitro cell targeting, there are limited in vivo studies, particularly for cancer imaging and therapy, due to poor stability or short systemic circulation times generally observed for these more complicated nanostructures. [16,17] Herein, we introduce long-circulating, micellar hybrid nanoparticles (MHN) that contain MN, QD, and the anti-cancer drug doxorubicin (DOX) within a single

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“…Magnetic nanoparticles have high potential for applications in diverse areas of highdensity magnetic storage media [1,2], magnetic resonance imaging [3], non-linear optics [4], ferrofluids [5], environmental remediation [6], catalysis [7] and biomedicine [8]. Theoretically, the magnetic properties of nanoparticles have been widely investigated by the use of various techniques, including the mean field model [9], effective-field theory [10][11][12], Monte Carlo simulations [13][14][15][16], Green's function technique [17][18] and Bethe Peiris approximation [19].…”

Section: Introductionmentioning

confidence: 99%

Effects of the random field on the magnetic behavior of a nanoparticle with core/shell morphology

Zaim

Kerouad

Boughrara

2012

EPJ Web of Conferences

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Abstract. We have used the effective field theory based on probability distribution method to investigate the hysteresis behavior of a magnetic nanoparticle with core/shell morphology in a random field. The hysteresis curves are obtained for different values of the random field and the temperature. We find a number of characteristic behaviors, such as the existence of double hysteresis loops for appropriate values of the system parameters. The remanent magnetization and the coercive field as a function of the temperature are examined.

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Designed Fabrication of Multifunctional Magnetic Gold Nanoshells and Their Application to Magnetic Resonance Imaging and Photothermal Therapy

Cited by 484 publications

References 54 publications

Maximizing surface-enhanced Raman scattering sensitivity of surfactant-free Ag-Fe3O4 nanocomposites through optimization of silver nanoparticle density and magnetic self-assembly

Maximizing surface-enhanced Raman scattering sensitivity of surfactant-free Ag-Fe3O4 nanocomposites through optimization of silver nanoparticle density and magnetic self-assembly

Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery

Effects of the random field on the magnetic behavior of a nanoparticle with core/shell morphology

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