Design, Ultrasonic-assisted Synthesis and Evaluation In vitro Antimicrobial Activity of Bis-isoxazole Derivatives Bearing Chloro-pyridinyl Group

Na2S2O3 Catalyzed Three‐Component Synthesis and Anti‐Bacterial Activity of 3‐Methyl‐4‐(hetero)arylmethylene isoxazole‐5(4H)‐ones

“…As a continuation of the previous work, [31,32] herein, we report an effective and novel one–pot three‐component synthesis of 3‐methyl‐4‐(hetero) arylmethylene isoxazole‐5(4 H )‐ones in water employing a cheap and environmental–friendly Na 2 S 2 O 3 as a catalyst, and 16 compounds were synthesized with moderate to high yields. Furthermore, the antibacterial activities of the obtained isoxazolone derivatives were evaluated using rifampicin as a positive control.…”

Regioselective Synthesis of Isoxazoles from Propargylic Alcohols via In‐situ‐formed α‐Iodo Enones/Enals

“…Isoxazoles are a type of azoles that contain adjacent oxygen and nitrogen heteroatoms. Compounds with isoxazole ring have numerous biological properties, [1] such as anti‐cancer, [2] anti‐bacterial, [3] anti‐fungal, [4] anti‐inflammatory, [5] anti‐proliferative [6] and disinfectant activities [7] . Reactions between hydroxylamine and β‐dicarbonyl compounds [8] or α,β‐enones [9] are the most frequently used routes to isoxazoles.…”

Effective Synthesis and Anti‐Mycobacterial Activity of Isoxazole‐Substituted Piperazine Derivatives

“…In our previous work, the synthesized isoxazole derivatives, showed remarkable antimicrobial activity [37,38] and quorum sensing activity [39] . Building upon the representative compounds bis‐isoxazole ethers, bis‐isoxazole derivatives bearing chloro‐pyridinyl group and bearing isoxazole ring at 1,4‐disubstituted triazoles, we focused on the design of new scaffolds using piperazine extended by different substituted isoxazole groups.…”