Design, synthesis, characterization of some new 1,2,3-triazolyl chalcone derivatives as potential anti-microbial, anti-oxidant and anti-cancer agents via a Claisen–Schmidt reaction approach

Abstract

A new series of 1,2,3-triazolyl chalcone derivatives (5a–k) and (6a–e) were synthesized and evaluated for their anti-microbial, anti-oxidant and anti-cancer activities.

Synthesis and Pharmacological Activities of Chalcone and Its Derivatives Bearing N-Heterocyclic Scaffolds: A Review

“…Recently, Bhat and co-workers reported a novel series of bioactive 1,2,3-triazolyl chalcone derivatives that were synthesized via the Claisen–Schimidt reaction . The antioxidant activities of the compounds were further evaluated using the ABTS (2,2′-azino-bis­(3-ethyl benzothiazoline-6-sulfonic acid)) antioxidant assay technique.…”

“…Recently, Bhat and co-workers reported a novel series of bioactive 1,2,3-triazolyl chalcone derivatives that were synthesized via the Claisen–Schimidt reaction. 59 The antioxidant activities of the compounds were further evaluated using the ABTS (2,2′-azino-bis(3-ethyl benzothiazoline-6-sulfonic acid)) antioxidant assay technique. Evaluation of the antioxidant activity revealed that most of the tested compounds exhibited moderate to excellent DPPH and ABTS radical scavenging potential compared to the positive control ascorbic acid.…”

Novel Pyrazole‐Chalcone Hybrids: Synthesis and Computational Insights Against Breast Cancer

“…Manjunatha Bhat et al. synthesized a novel series of 1, 3‐diphenyl‐pyrazole‐chalcones with 1‐phenyl‐1,2,3‐triazole, among them compound 1 & 2 showed excellent anti‐proliferative activity against BC cell lines [32] . Additionally, Sankappa Rai U. et al.…”

“…Manjunatha Bhat et al synthesized a novel series of 1, 3-diphenyl-pyrazole-chalcones with 1-phenyl-1,2,3triazole, among them compound 1 & 2 showed excellent antiproliferative activity against BC cell lines. [32] Additionally, Sankappa Rai U. et al have successfully synthesized novel 3phenyl-4-alkyl-pyrazole-chalcone derivatives through strategic conjugation with various heterocycles, subsequently evaluating their anticancer potential on the Michigan Cancer Foundation-7 (MCF-7) cell line. Remarkably, derivative 3, featuring a 5- fluoropyridin-2-yl-pyrazole chalcone structure, exhibited exceptional potency with a half-maximal inhibitory concentration (IC 50 ) of 0.047 μM, surpassing the reference standard doxorubicin.…”

All-inorganic lead halide perovskites for photocatalysis: a review

“…TiO 2 was originally used as a photocatalyst to break down water into H 2 and O 2 . 5 Different catalysts have been employed, including metal oxides (ZnO, WO 3 , Co 2 O, CeO 2 ), [6][7][8] metal suldes (MoS 2 , WS 2 , Co 3 S 4 ), [9][10][11][12][13][14] nitrides (C 3 N 4 , GaN), 15,16 phosphides (InP, Ni 2 P, CoP, FeP), [17][18][19][20][21][22][23][24][25][26] and carbides (C 3 N 4 , rGO, MoC). [27][28][29][30][31] Photocatalysts with band gap (E g ) larger than 3 eV, such as TiO 2 , ZnO, and MnS, have a fatal aw: they can only be activated by UV light and cannot respond to a wide range of visible light regions.…”