Design, Synthesis, Characterization, and In Vitro Evaluation of a New Cross-Linked Hyaluronic Acid for Pharmaceutical and Cosmetic Applications

Sciabica, Sabrina; Tafuro, Giovanni; Semenzato, Alessandra; Traini, Daniela; Silva, Dina M.; Reis, Larissa Gomes dos; Canilli, Luisa; Terno, Massimo; Durini, Elisa; Vertuani, Silvia; Baldisserotto, Anna; Manfredini, Stefano

doi:10.3390/pharmaceutics13101672

Cited by 10 publications

(4 citation statements)

References 58 publications

(70 reference statements)

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“…On the whole, the resistance of the synthesized HA silica hydrogels to shear, compression, and tension is lower in comparison with the covalently cross-linking HA using organic agents [ 78 , 79 , 80 ] or alkoxysilanes [ 34 , 35 , 36 , 37 ]. However, topical or injectable delivery of anti-inflammatory drugs does not require hydrogels with very high mechanical properties.…”

Section: Discussionmentioning

confidence: 99%

Silica Hydrogels as Platform for Delivery of Hyaluronic Acid

Parfenyuk

Dolinina

2022

Pharmaceutics

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Hyaluronic acid (HA) is chondroprotective and anti-inflammatory drug used clinically for treatment of inflammatory disorders (arthritis, skin diseases, bowel diseases, etc.). In addition, HA is a crucial ingredient in the cosmetic products used to eliminate the unpleasant consequences of inflammatory skin diseases. The main disadvantages that limit its use are its low mechanical properties and its rapid biodegradation. In this paper, silica hydrogels are considered as a promising matrix for HA to improve its properties. The hybrid HA-silica hydrogels were synthesized by the sol–gel method. Morphology of the hydrogels was investigated by optical microscopy and scanning electron microscopy methods. Taking into account their potential applications for topical and injectable delivery, much attention was paid to investigation of deformation properties of the hydrogels under shear, compression, and tension. Their resistance to enzymatic degradation in vitro was estimated. Kinetics and mechanisms of HA release from the hybrid hydrogels in vitro were also studied. It was found that the indicated properties can be controlled by synthesis conditions, HA molecular weight, and its loading in the hydrogels. Silica hydrogels are a prospective platform for the development of new soft formulations and cosmetic compositions of HA with improved pharmacological and consumer properties.

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Section: Discussionmentioning

confidence: 99%

Silica Hydrogels as Platform for Delivery of Hyaluronic Acid

Parfenyuk

Dolinina

2022

Pharmaceutics

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“…HA is widely utilized in biomedical applications due to its biodegradable, mucoadhesive, hygroscopic, and viscoelastic properties and is extensively utilized in cosmeceuticals, [ 231 ] ophthalmology, [ 232 ] rheumatology, [ 233 ] urology, [ 234 ] oncology, [ 235 ] pharmaceuticals, [ 236 ] as well as in drug delivery and tissue engineering applications. HA is also widely utilized in the wound healing context due to its hemostatic, anti‐inflammatory, and immunomodulatory properties.…”

Section: Natural Polymers For Skin Repair and Regeneration: Polysacch...mentioning

confidence: 99%

Natural Polymer‐Based Materials for Wound Healing Applications

Ho,

Tran,

Doan

et al. 2024

Advanced NanoBiomed Research

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Skin injuries pose significant health challenges, with conditions like burns and diabetic, venous, and pressure ulcers presenting complex wound management scenarios. Effective wound care strategies for these injuries encompass a range of interventions, from simple wound dressings to bioactive materials and surgical procedures involving skin substitutes and skin grafting. This review explores the potential of natural polymers, including silk, collagen, gelatin, elastin, cellulose, chitosan, alginate, and hyaluronic acid, in wound management. Natural polymers offer several advantages, including abundance, biodegradability, and compatibility with traditional and modern material fabrication techniques, and have demonstrated safety and efficacy in clinical applications, modulating various facets of the wound healing process. Highlighting preclinical and clinical studies, along with commercial products, this review showcases the versatility and utility of natural polymers in wound management and provides insights into emerging developments, such as 3D bioprinting and stimuli‐responsive materials, which hold promise for personalized wound treatments. Additionally, we discuss the importance of the material format and morphology in engineering the next generation of wound dressings and skin substitutes, offering a pathway to optimize natural polymers for enhanced wound healing outcomes.

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“…Due to its regulatory role in wound repair and re‐epithelialization processes, as well as its stimulation of collagen production, it is widely used as an anti‐wrinkle agent and dermal filler. HA has high hygroscopicity, absorbing a large amount of water to provide hydration, and its molecular weight determines its application as a physical barrier (Sciabica et al, 2021). Therefore, HA is widely used in the cosmetics and pharmaceutical fields.…”

Section: Introductionmentioning

confidence: 99%

Study on the aggregation nature of sodium cocoyl glycinate and sodium hyaluronate mixture in aqueous and NaCl solutions

Wang,

Guo,

Zan

et al. 2024

J Surfact & Detergents

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The mixed system of sodium cocoyl glycinate and sodium hyaluronate (HA) with different mass concentrations and relative molecular weights was investigated by the surface tension method. All the curves of surface tension versus logarithm of concentration (γ‐lgc curves) of sodium cocoyl glycinate‐HA mixed system displayed the properties of double platform. The critical micelle concentration (cmc) of sodium cocoyl glycinate was 1.690 g/L at 25°C. The two inflection points of the γ‐lgc curves corresponding to the cocoyl glycine‐HA mixed system were cac (the critical aggregation concentration) and cmce (the extended cmc of sodium cocoyl glycinate), and cac < cmce < cmc. With the change of the mass concentration and relative molecular weight of HA, the cac values were almost constant. However, cmce increased with the increase of the mass concentration of HA at the same HA molecular weight. For the HA of molecular weight of 800 and 260000 Da, the mass concentration of HA increased from 0.05 to 0.4 g/L, and the cmce value increased from 1.199 to 1.390 g/L and 1.102 to 1.330 g/L, respectively. When the mass concentration of HA remained the same, the change in the relative molecular weight of HA had little effect on the cmce value. For the mixed system of sodium cocoyl glycine −0.1 g/L HA, when the concentration of NaCl was 2 g/L, the salt enhancement effect was dominant. When the concentration of NaCl was 4 to 8 g/L, the salt weakening effect was dominant. It is indicated that HA can improve the chemical properties of sodium cocoyl glycinate at a certain concentration, thus improving the cleaning, foaming, and foam stability of sodium cocoyl glycinate.

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Design, Synthesis, Characterization, and In Vitro Evaluation of a New Cross-Linked Hyaluronic Acid for Pharmaceutical and Cosmetic Applications

Cited by 10 publications

References 58 publications

Silica Hydrogels as Platform for Delivery of Hyaluronic Acid

Silica Hydrogels as Platform for Delivery of Hyaluronic Acid

Natural Polymer‐Based Materials for Wound Healing Applications

Study on the aggregation nature of sodium cocoyl glycinate and sodium hyaluronate mixture in aqueous and NaCl solutions

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