Design, synthesis, biological evaluation and molecular dynamics of some novel 3-phenylpyrazolo[1,5-
 a
 ]pyrimidine-2,7(1
 H
 ,4
 H
 )-dione based compounds as anti-tubercular agents

Chauhan, Monica; Prajapati, Chintu; Mirza, Sadaf; Barot, Rahul; Yadav, Rasana; Barmade, Mahesh; Kakadiya, Dhruvi; Vijayvargia, Ravi; Haobam, Bijaya; Baidya, Anurag TK; Kumar, Rajnish; Yadav, M. R.; Murumkar, Prashant

doi:10.1080/07391102.2023.2249109

Journal of Biomolecular Structure and Dynamics

2023

DOI: 10.1080/07391102.2023.2249109

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Design, synthesis, biological evaluation and molecular dynamics of some novel 3-phenylpyrazolo[1,5- a ]pyrimidine-2,7(1 H ,4 H )-dione based compounds as anti-tubercular agents

Monica Chauhan,

Chintu Prajapati,

Sadaf Mirza

et al.

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2024

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The Mycobacterium tuberculosis Cell Wall: An Alluring Drug Target for Developing Newer Anti‐TB Drugs—A Perspective

Chauhan,

Barot,

Yadav

et al. 2024

Chem Biol Drug Des

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The Mycobacterium cell wall is a capsule‐like structure comprising of various layers of biomolecules such as mycolic acid, peptidoglycans, and arabinogalactans, which provide the Mycobacteria a sort of cellular shield. Drugs like isoniazid, ethambutol, cycloserine, delamanid, and pretomanid inhibit cell wall synthesis by inhibiting one or the other enzymes involved in cell wall synthesis. Many enzymes present across these layers serve as potential targets for the design and development of newer anti‐TB drugs. Some of these targets are currently being exploited as the most druggable targets like DprE1, InhA, and MmpL3. Many of the anti‐TB agents present in clinical trials inhibit cell wall synthesis. The present article covers a systematic perspective of developing cell wall inhibitors targeting various enzymes involved in cell wall biosynthesis as potential drug candidates for treating Mtb infection.

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The Mycobacterium tuberculosis Cell Wall: An Alluring Drug Target for Developing Newer Anti‐TB Drugs—A Perspective

Chauhan,

Barot,

Yadav

et al. 2024

Chem Biol Drug Des

View full text Add to dashboard Cite

show abstract

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Design, synthesis, biological evaluation and molecular dynamics of some novel 3-phenylpyrazolo[1,5- a ]pyrimidine-2,7(1 H ,4 H )-dione based compounds as anti-tubercular agents

Cited by 1 publication

References 58 publications

The Mycobacterium tuberculosis Cell Wall: An Alluring Drug Target for Developing Newer Anti‐TB Drugs—A Perspective

The Mycobacterium tuberculosis Cell Wall: An Alluring Drug Target for Developing Newer Anti‐TB Drugs—A Perspective

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