Design, synthesis, bioactivity and mechanism of action of novel myricetin derivatives containing amide and hydrazide

Cao, Xiaohong; Liu, Fang; He, Bangcan; Li, Xing; Zhang, Yuanquan; Zhang, Nian; Xue, Wei

doi:10.1016/j.arabjc.2023.104588

Cited by 9 publications

(2 citation statements)

References 44 publications

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“…In order to investigate the mechanism of action of the compounds, chlorophyll a, chlorophyll b, and total chlorophyll contents of A26-treated and unsprayed tobacco leaves were determined after virus infection by referring to the method reported in the literature. 47 The experimental methodology was described in the ESI. † 2.3.5 Malondialdehyde content test.…”

Section: -(3-((57-dimethoxymentioning

confidence: 99%

Design, synthesis, and antiviral activities of myricetin derivatives containing pyridazinone

Xing,

An,

Qin

et al. 2024

New J. Chem.

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Section: -(3-((57-dimethoxymentioning

confidence: 99%

Design, synthesis, and antiviral activities of myricetin derivatives containing pyridazinone

Xing,

An,

Qin

et al. 2024

New J. Chem.

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“…Many compounds comprising the piperidine linker have been developed as commercial pharmaceuticals and pesticides so far, such as fungicides Oxathiapiprolin & Fluoxapiprolin (Figure ), N -methyl- d -aspartate (NDMA) receptor antagonist Ifenprodil, and acetylcholinesterase (AChE) inhibitor Donepezil. On the other hand, the hydrazide functional group is widely studied and exploited owing to its broad-spectrum bioactivities, such as antifungal, , insecticidal, herbicidal, antibacterial, antiviral, and anticancer effects. The hydrazide-based commercial agrochemicals include the fungicide Miexiuyihao, plant growth regulator Daminozide, and insecticide Tebufenozide.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, Antifungal Activity, and Mechanism of Action of New Piperidine-4-carbohydrazide Derivatives Bearing a Quinazolinyl Moiety

Yang,

Liu,

Yan

et al. 2024

J. Agric. Food Chem.

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A series of new piperidine-4-carbohydrazide derivatives bearing a quinazolinyl moiety were prepared and evaluated for their fungicidal activities against agriculturally important fungi. Among these derivatives, the chemical structure of compound A45 was clearly verified by X-ray crystallographic analysis. The antifungal bioassays revealed that many compounds in this series possessed good to excellent inhibition effects toward the tested fungi. For example, compounds A13 and A41 had EC 50 values of 0.83 and 0.88 μg/mL against Rhizoctonia solani in vitro, respectively, superior to those of positive controls Chlorothalonil and Boscalid (1.64 and 0.96 μg/mL, respectively). Additionally, the above two compounds also exhibited notable inhibitory activities against Verticillium dahliae (with EC 50 values of 1.12 and 3.20 μg/mL, respectively), far better than the positive controls Carbendazim and Chlorothalonil (19.3 and 11.0 μg/mL, respectively). More importantly, compound A13 could potently inhibit the proliferation of R. solani in the potted rice plants, showing good in vivo curative and protective efficiencies of 76.9% and 76.6% at 200 μg/mL, respectively. Furthermore, compound A13 demonstrated an effective inhibition of succinate dehydrogenase (SDH) activity in vitro with an IC 50 value of 6.07 μM. Finally, the molecular docking study revealed that this compound could be well embedded into the active pocket of SDH via multiple noncovalent interactions, involving residues like SER39, ARG43, and GLY46.

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Novel flavonol derivatives containing benzoxazole as potential antiviral agents: design, synthesis, and biological evaluation

Zhou,

Sun,

Zhou

et al. 2024

Mol Divers

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Design, synthesis, bioactivity and mechanism of action of novel myricetin derivatives containing amide and hydrazide

Cited by 9 publications

References 44 publications

Design, synthesis, and antiviral activities of myricetin derivatives containing pyridazinone

Design, synthesis, and antiviral activities of myricetin derivatives containing pyridazinone

Design, Synthesis, Antifungal Activity, and Mechanism of Action of New Piperidine-4-carbohydrazide Derivatives Bearing a Quinazolinyl Moiety

Novel flavonol derivatives containing benzoxazole as potential antiviral agents: design, synthesis, and biological evaluation

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