Design, synthesis, antifungal evaluation and mechanism study of novel norbornene derivatives as potential laccase inhibitors
Dao‐Jun Jin,
Zi‐Hui Yang,
Yi‐Gui Qiu
et al.
Abstract:BACKGROUNDTo discover novel fungicide candidates, five series of novel norbornene hydrazide, bishydrazide, oxadiazole, carboxamide and acylthiourea derivatives (2a‐2 t, 3a‐3 f, 4a‐4 f, 5a‐5 f and 7a‐7 f) were designed, synthesized and assayed for their antifungal activity toward seven representative plant fungal pathogens.RESULTSIn the in vitro antifungal assay, some title norbornene derivatives presented good antifungal activity against Botryosphaeria dothidea, Sclerotinia sclerotiorum and Fusarium graminearu… Show more
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