Design, synthesis, anticancer activity and molecular docking analysis of novel dinitrophenylpyrazole bearing 1,2,3-triazoles

Suryanarayana, Kotyada; Robert, Alice R.; Kerru, Nagaraju; Pooventhiran, T.; Thomas, Renjith; Maddila, Suresh; Jonnalagadda, Sreekantha B.

doi:10.1016/j.molstruc.2021.130865

Cited by 29 publications

(7 citation statements)

References 51 publications

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“…These novel molecules were examined for anticancer activity against three tumor cell lines, namely human epithelial colorectal adenocarcinoma (CECA), cervical carcinoma (HeLa), and breast adenocarcinoma (MCF-7). Compound 71 showed potent activity at IC 50 values 08, 06, and 12 μM, respectively, whereas control combretastatin-A4 had IC 50 values of 10, 9 and 11 μM, respectively [ 193 ]. Chandrashekhar et al (2016) synthesized triazole- myrrhanone hybrids and tested them for anticancer activity against various cell lines, including A549, Hela, MCF-7, DU-I45, and HepG2.…”

Section: Current Advances In Nitrogen Containing Heterocycles As Anti...mentioning

confidence: 99%

Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

Kumar

Singh

et al. 2023

Pharmaceuticals

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Cancer is one of the major healthcare challenges across the globe. Several anticancer drugs are available on the market but they either lack specificity or have poor safety, severe side effects, and suffer from resistance. So, there is a dire need to develop safer and target-specific anticancer drugs. More than 85% of all physiologically active pharmaceuticals are heterocycles or contain at least one heteroatom. Nitrogen heterocycles constituting the most common heterocyclic framework. In this study, we have compiled the FDA approved heterocyclic drugs with nitrogen atoms and their pharmacological properties. Moreover, we have reported nitrogen containing heterocycles, including pyrimidine, quinolone, carbazole, pyridine, imidazole, benzimidazole, triazole, β-lactam, indole, pyrazole, quinazoline, quinoxaline, isatin, pyrrolo-benzodiazepines, and pyrido[2,3-d]pyrimidines, which are used in the treatment of different types of cancer, concurrently covering the biochemical mechanisms of action and cellular targets.

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Section: Current Advances In Nitrogen Containing Heterocycles As Anti...mentioning

confidence: 99%

Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

Kumar

Singh

et al. 2023

Pharmaceuticals

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“…Recently, newly design 1,2,3-triazole-based anticancer agents have been reported along with their possible modes of actions against wide range types of molecular targets. Molecular docking studies suggested that the 1,2,3-triazole based compounds could occupy in the binding sites of DNA topoisomerase-II, 68 histone deacetylase 2 (HDAC2), 69 cyclooxygenase-2 (COX-2), 70 metalloproteinases (MMP-2 and MMP-9), 71 oncogenic kinase PAK1, 72 c-MET, 41 some cancer proteins, 73 carbonic anhydrase, 74 EGFR, 75 and glycogen synthase kinase-3 (GSK-3). 76 The significant roles of the triazole ring (presented in the molecule) in the formation of ligand-binding interactions of the triazole-containing compounds were noted from several studies.…”

Section: Roles Of the 123-triazole Ring In Ligand-anticancer Targets ...mentioning

confidence: 99%

1,2,3-Triazole Scaffold in Recent Medicinal Applications: Synthesis and Anticancer Potentials

Pingaew,

Choomuenwai,

Leechaisit

et al. 2022

HETEROCYCLES

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Cancer is one of commonly concerned health problems globally and its management is challenging. Besides an availability of diverse classes of anticancer agents, the existing drugs are noted for their limitations such as considerable toxicities, low potency and responsiveness, drug resistance, and others. 1,2,3-Triazole is an attractive heterocyclic scaffold possessing considerable characteristics and is presented in many pharmacologically active molecules.Accordingly, attention has been given to this scaffold in the recent years, especially, in an area of anticancer drug development. In this review, a collection of recently reported triazole based anticancer agents are discussed along with their synthetic methods, proposed molecular targets, and mechanisms of actions. A summary of other recently reported biological activities is also provided. In overview, recent studies suggested that the 1,2,3-triazole based compounds could elicit their anticancer effects against several cancer cell lines via an inhibition of cancer cell growth, an induction of apoptosis, an inhibition of involved enzymes such as aromatase, kinases, and others. Some interesting results from computational studies also discussed relating to the predictions of possible molecular targets. In summary, it is suggested that the 1,2,3-triazole serves as a potential scaffold with noteworthy

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“… 9 - 11 Pyridine is a six-membered moiety among heterocyclic compounds which possess vast applicability in pharmaceuticals and agrochemicals. 12 , 13 There is a clear medical need to create novel antiviral medicines, especially with the rise in medication resistance. Antimicrobial, antiviral, antioxidant, anti-diabetic, anti-cancer, anti-malarial, analgesic, and anti-inflammatory effects are all demonstrated by various derivatives of the pyridine scaffold.…”

Section: Introductionmentioning

confidence: 99%

Pyridine Derivatives as Potential Inhibitors for Coronavirus SARS-CoV-2: A Molecular Docking Study

Karthick

Swarnalatha

2023

Bioinform Biol Insights

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Coronavirus SARS-CoV-2, a causative agent for the global epidemic disease COVID-19, which has a highest modality rate. Several initiatives have been undertaken to repurpose current antiviral medications and tested the classic pyridine derivatives (PyDev), which have showed substantial therapeutic potential against a variety of illnesses and also have several biological functions such as, antibacterial, antiviral, and anti-inflammatory. However, limited reports are available for the treatment of Coronavirus SARS-CoV-2 using PyDev. Hence, the possibilities of the best-described PyDev molecules of powerful Coronavirus SARS-CoV-2 inhibitors have been attempted in this investigation. This study primarily focused on blocking four key targets of Coronavirus SARS-CoV-2 proteins. Terpyridine has shown the greatest inhibitory potential (with a binding energy of −8.8 kcal/mol) against all four coronavirus targets. This study results would pave the potential lead medication for Coronavirus SARS-CoV-2 therapeutic strategies.

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Design, synthesis, anticancer activity and molecular docking analysis of novel dinitrophenylpyrazole bearing 1,2,3-triazoles

Cited by 29 publications

References 51 publications

Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

1,2,3-Triazole Scaffold in Recent Medicinal Applications: Synthesis and Anticancer Potentials

Pyridine Derivatives as Potential Inhibitors for Coronavirus SARS-CoV-2: A Molecular Docking Study

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