Design, synthesis, antibiofilm, quorum sensing inhibition, anticancer and docking studies of novel 2-(4-acridine-9-ylamino)isoindoline-1,3-dione

Mane, Smita; Katagi, Kariyappa S.; Bhasme, Pramod; Pattar, Sridhar; Wei, Qing; Joshi, Shrinivas D.

doi:10.1016/j.cdc.2019.100198

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…Among all compounds, compound 39 inhibited approximately 70% of Pseudomonas aeruginosa biofilms while the remaining compounds showed mild inhibition of biofilm. Considering all these compounds, compound 39f with nitro substitution may be important to eradicate biofilms 136 ( Fig. 22 ).…”

Section: Targeting Virulence Factormentioning

confidence: 99%

Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance

et al. 2021

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Section: Targeting Virulence Factormentioning

confidence: 99%

Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance

et al. 2021

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“…Other synthetic azole and triazine derivatives of phthalimide have also demonstrated antimicrobial activity against several pathogens (Asadi et al, 2023;Yadav et al, 2023). A study demonstrated that the acridine-isoindoline phthalimide derivatives showed an anti-biofilm effect on Pseudomonas aeruginosa biofilms (Mane et al, 2019). Moreover, amphiphilic quaternized chitosan with phthalimide functional groups also demonstrated anti-biofilm activity against Streptococcus mutans (Vijayakumar et al, 2021;Phuangkaew et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Antifungal, anti-biofilm, and anti-hyphal properties of N-substituted phthalimide derivatives against Candida species

Shaik,

Lee,

Kim

et al. 2024

Front. Cell. Infect. Microbiol.

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Candida species comprise a ubiquitous pathogenic fungal genus responsible for causing candidiasis. They are one of the primary causatives of several mucosal and systemic infections in humans and can survive in various environments. In this study, we investigated the antifungal, anti-biofilm, and anti-hyphal effects of six N-substituted phthalimides against three Candida species. Of the derivatives, N-butylphthalimide (NBP) was the most potent, with a minimum inhibitory concentration (MIC) of 100 µg/ml and which dose-dependently inhibited biofilm at sub-inhibitory concentrations (10–50 µg/ml) in both the fluconazole-resistant and fluconazole-sensitive Candida albicans and Candida parapsilosis. NBP also effectively inhibited biofilm formation in other pathogens including uropathogenic Escherichia coli, Staphylococcus epidermidis, Staphylococcus aureus, and Vibrio parahaemolyticus, along with the polymicrobial biofilms of S. epidermidis and C. albicans. NBP markedly inhibited the hyphal formation and cell aggregation of C. albicans and altered its colony morphology in a dose-dependent manner. Gene expression analysis showed that NBP significantly downregulated the expression of important hyphal- and biofilm-associated genes, i.e., ECE1, HWP1, and UME6, upon treatment. NBP also exhibited mild toxicity at concentrations ranging from 2 to 20 µg/ml in a nematode model. Therefore, this study suggests that NBP has anti-biofilm and antifungal potential against various Candida strains.

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Synthesis of 1,2-dihydroacridines based on chloroquinoline-3-carbaldehyde and diketene under catalyst-free reaction

et al. 2023

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Design, synthesis, antibiofilm, quorum sensing inhibition, anticancer and docking studies of novel 2-(4-acridine-9-ylamino)isoindoline-1,3-dione

Cited by 6 publications

References 34 publications

Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance

Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance

Antifungal, anti-biofilm, and anti-hyphal properties of N-substituted phthalimide derivatives against Candida species

Synthesis of 1,2-dihydroacridines based on chloroquinoline-3-carbaldehyde and diketene under catalyst-free reaction

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