Design, Synthesis, and Toxicological Activities of Novel Insect Growth Regulators as Insecticidal Agents against <i>Spodoptera littoralis</i> (Boisd.)

Abdelhamid, Antar A.; Aref, Safwat A.; Ahmed, Nabila A.; El‐Saghier, Ahmed M. M.; Latif, Fawy M. Abd El; Alghamdi, Sameera A.; Gad, Mohamed A.

doi:10.1021/acsomega.2c05977

Cited by 22 publications

(23 citation statements)

References 27 publications

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“…We have discovered novel pyridine and thiazole derivatives, which showed excellent insecticidal activity against nymphs and adults of S. oleae . The insecticidal activity of all the pyridine and thiazole derivatives was measured via leaf dip bioassay methods [13–22] …”

Section: Resultsmentioning

confidence: 99%

“…The insecticidal activity of all the pyridine and thiazole derivatives was measured via leaf dip bioassay methods. [13][14][15][16][17][18][19][20][21][22]…”

Section: Insecticidal Activitymentioning

confidence: 99%

“…The black scale, Saissetia oleae (Olivier, 1791) (Hemiptera: Coccidae) is an important pest of citrus and olive trees. Originally from South Africa, this scale is now distributed worldwide [17] . In Egypt, black scale is found on citrus (Citrus spp.…”

Section: Introductionmentioning

confidence: 99%

“…Originally from South Africa, this scale is now distributed worldwide. [17] In Egypt, black scale is found on citrus (Citrus spp. ), cultivated olive (Oleaeuropaea L.), avocado (Perseaamericana Mill.…”

Section: Introductionmentioning

confidence: 99%

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Design and Synthesis of Pyridine and Thiazole Derivatives as Eco‐friendly Insecticidal to Control Olive Pests

Elkanzi,

Al‐Hazmi,

Bakr

et al. 2023

Chemistry & Biodiversity

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Treatment of p-tosyloxybenzaldehyde (1) with ethyl cyanoacetate afforded ethyl 2-cyano-3-(4-{[(4-methylphenyl)sulfonyl]oxy} phenyl)acrylate (2) which reacted with some active methylene derivatives under microwave irradiation in presence of ammonium acetate yielded pyridine derivatives 3-7. On the other hand, when treatment of compound 1 with thiosemicarbazide gave 4-tosyloxybenzylidenethiosemicarbazone (8), which allowed to react with some active methylene compounds, such as: ethyl bromoacetate, chloroacetonitrile or phenacyl bromide derivatives gave thiazole derivatives 9-13. The structure of all products were confirmed by elemental and spectroscopic analyses such as IR, 1 H-NMR, 13 CNMR and mass spectra. The advanced of this method are short reaction time (3-7 min), excellent yield, pure products, and low-cost processing. In the final category, the toxicological characteristics of all compounds were tested towards Saissetia oleae (Olivier, 1791) (Hemiptera: Coccidae). With respect to the LC 50 values. It has been found that compound 3 possesses the highest insecticidal bioefficacy compared with other products, with values of 0.502 and 1.009 ppm, for nymphs and adults female, respectively. This study paves the way towards discovering new materials for potential use as insecticidal active agents.

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Section: Resultsmentioning

confidence: 99%

“…The insecticidal activity of all the pyridine and thiazole derivatives was measured via leaf dip bioassay methods. [13][14][15][16][17][18][19][20][21][22]…”

Section: Insecticidal Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Design and Synthesis of Pyridine and Thiazole Derivatives as Eco‐friendly Insecticidal to Control Olive Pests

Elkanzi,

Al‐Hazmi,

Bakr

et al. 2023

Chemistry & Biodiversity

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“…The toxicological activities of target pyridine analogues were calculated using the leaf dipping technique under the same reported laboratory conditions. − Thus, we prepared five concentrations of all compounds dissolved in drops of dimethylformamide with the use of 0.1% Tween-80 as a surfactant. An identical size of 30 adults and also 30 nymphs of cowpea aphid insects were dipped for 10 s in each concentration of each compound “repeated three times”.…”

Section: Materials and Techniquesmentioning

confidence: 99%

Functionalized Pyridines: Synthesis and Toxicity Evaluation of Potential Insecticidal Agents against Aphis craccivora

et al. 2023

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Using ultrasound technology instead of traditional methods, some pyridine derivatives were prepared by a simple procedure via a four-component reaction of different aromatic aldehydes, acetyl aryl, sodium alkoxide, and malononitrile, and additionally, all prepared compounds were monitored for insecticidal activities toward nymphs and adults of cowpea aphid. Though a lot of insecticides are discovered as a novelty on the other hand, neonicotinoid compounds are reflected as the most affected insecticides against aphids and many other pests. Thus, some of the pyridine derivatives were chemically prepared as analogues to a large group of insecticides called neonicotinoids. Under laboratory conditions, the toxicity of these components was measured toward adults and nymphs of Aphis craccivora. With respect to the LC50 values, components 1f, 1d, and 1c have the utmost insecticidal bioactivity, with values of 0.080, 0.098, and 0.127 mg/L. This work covers the way to discover novel compounds for the prospective use as insecticidal representatives.

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Design, Characterization and SAR Studies of Novel Bioactive Benzylideneacetophenone Derivatives as Insecticidal Agents against Spodoptera frugiperda (Lepidoptera: Noctuidae)

Abd El‐Lateef,

Elkanzi,

Adel Thabet

et al. 2023

Chemistry & Biodiversity

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Unintentional environmental effects brought on by insecticides encourage the creation of safer substitutes. A very polyphagous migrating lepidopteran pest species in Africa called S. Frugiperda causes terrible damage. In the current paper, treatment of 4‐acetylphenyl 4‐methylbenzenesulfonate with different aromatic aldehydes in the presence of NaOH afforded benzylideneacetophenones. The structure of the newly prepared compounds were proved by different spectroscopic techniques such as IR, 1H‐NMR, 13C NMR, and elemental analysis. We looked at the association between contact with S. frugiperda and stricture reaction to examine their harmful effect. Additionally, S. frugiperda was used for testing the newly created compounds for their ability to kill insects. The majority of substances have been proven to be effective and promising. It has been found that 4‐[3‐(4‐Methylphenyl)prop‐2‐enoyl]phenyl‐4‐methyl benzenesulfonate (4) was the most active with an LC50=3.46 mg/L of 2nd instar larvae and LC50=9.45 mg/L of 4th instar larvae. Moreover, some of biological and histopathological aspects of the synthesized products were investigated under laboratory conditions.

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Design, Synthesis, and Toxicological Activities of Novel Insect Growth Regulators as Insecticidal Agents against Spodoptera littoralis (Boisd.)

Cited by 22 publications

References 27 publications

Design and Synthesis of Pyridine and Thiazole Derivatives as Eco‐friendly Insecticidal to Control Olive Pests

Design and Synthesis of Pyridine and Thiazole Derivatives as Eco‐friendly Insecticidal to Control Olive Pests

Functionalized Pyridines: Synthesis and Toxicity Evaluation of Potential Insecticidal Agents against Aphis craccivora

Design, Characterization and SAR Studies of Novel Bioactive Benzylideneacetophenone Derivatives as Insecticidal Agents against Spodoptera frugiperda (Lepidoptera: Noctuidae)

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