Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease

Shen, Zhen-Bao; Meng, Hua-Wen; Meng, Xian-She; Lv, Ze-Kun; Fang, Mengyuan; Zhang, Lang-Lang; Lv, Zhi-Lin; Li, Musen; Liu, Ankang; Han, Jihong; Li, Qing-Shan; Duan, Yajun

doi:10.1016/j.ejmech.2023.115417

Cited by 7 publications

(2 citation statements)

References 44 publications

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“…The up-regulation of DMT1 ensuing from α-Syn overexpression also exerts a profound influence on the enhancement of iron uptake and the dysfunction of iron metabolism evidenced in PD [ 521 ]. Furthermore, the distorted expression and functionality of proteins involved in iron homeostasis have been detected in PD, further substantiating the association between iron dysregulation and the disease [ 504 , 509 , 510 , 522 , 523 ].…”

Section: Ferroptosis In Pathologiesmentioning

confidence: 84%

The mechanism of ferroptosis and its related diseases

Feng,

Tang,

Wang

et al. 2023

Mol Biomed

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Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of cellular metabolism, oxidative stress, and disease pathology. We have witnessed a mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological and pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, and traumatic tissue injuries. By unraveling the intricate underpinnings of the molecular machinery, pivotal contributors, intricate signaling conduits, and regulatory networks governing ferroptosis, researchers aim to bridge the gap between the intricacies of this unique mode of cellular death and its multifaceted implications for health and disease. In light of the rapidly advancing landscape of ferroptosis research, we present a comprehensive review aiming at the extensive implications of ferroptosis in the origins and progress of human diseases. This review concludes with a careful analysis of potential treatment approaches carefully designed to either inhibit or promote ferroptosis. Additionally, we have succinctly summarized the potential therapeutic targets and compounds that hold promise in targeting ferroptosis within various diseases. This pivotal facet underscores the burgeoning possibilities for manipulating ferroptosis as a therapeutic strategy. In summary, this review enriched the insights of both investigators and practitioners, while fostering an elevated comprehension of ferroptosis and its latent translational utilities. By revealing the basic processes and investigating treatment possibilities, this review provides a crucial resource for scientists and medical practitioners, aiding in a deep understanding of ferroptosis and its effects in various disease situations.

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Section: Ferroptosis In Pathologiesmentioning

confidence: 84%

The mechanism of ferroptosis and its related diseases

Feng,

Tang,

Wang

et al. 2023

Mol Biomed

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“…Tea is recognized as the optimal source of nutritional flavonoids, which the human body is incapable of synthesizing [3]; it has significant effects on human body, including enzyme regulation, improvement of blood circulation, regulation of cell apoptosis, prevention of abnormal fat accumulation, anticancer properties, inhibition of periodontal disease, antioxidant properties, weight loss, blood sugar reduction, and attenuation of neurodegeneration, such as Parkinson's disease (PD), Alzheimer's disease (AD), etc. [4][5][6][7][8][9][10][11][12][13]. In addition, research has shown that total flavonoids can serve as an innovative versatile electrolyte additive to enhance the cycling efficiency of high-voltage LiNiMnCoO 2 lithiumion batteries [14].…”

Section: Introductionmentioning

confidence: 99%

Prediction Model of Flavonoids Content in Ancient Tree Sun−Dried Green Tea under Abiotic Stress Based on LASSO−Cox

Li,

Wu,

Wang

et al. 2024

Agriculture

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To investigate the variation in flavonoids content in ancient tree sun–dried green tea under abiotic stress environmental conditions, this study determined the flavonoids content in ancient tree sun−dried green tea and analyzed its correlation with corresponding factors such as the age, height, altitude, and soil composition of the tree. This study uses two machine−learning models, Least Absolute Shrinkage and Selection Operator (LASSO) regression and Cox regression, to build a predictive model based on the selection of effective variables. During the process, bootstrap was used to expand the dataset for single−factor and multi−factor comparative analyses, as well as for model validation, and the goodness−of−fit was assessed using the Akaike information criterion (AIC). The results showed that pH, total potassium, nitrate nitrogen, available phosphorus, hydrolytic nitrogen, and ammonium nitrogen have a high accuracy in predicting the flavonoids content of this model and have a synergistic effect on the production of flavonoids in the ancient tree tea. In this prediction model, when the flavonoids content was >6‰, the area under the curve of the training set and validation set were 0.8121 and 0.792 and, when the flavonoids content was >9‰, the area under the curve of the training set and validation set were 0.877 and 0.889, demonstrating good consistency. Compared to modeling with all significantly correlated factors (p < 0.05), the AIC decreased by 32.534%. Simultaneously, a visualization system for predicting flavonoids content in ancient tree sun−dried green tea was developed based on a nomogram model. The model was externally validated using actual measurement data and achieved an accuracy rate of 83.33%. Therefore, this study offers a scientific theoretical foundation for explaining the forecast and interference of the quality of ancient tree sun−dried green tea under abiotic stress.

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Eco‐friendly approaches to 1,3,4‐oxadiazole derivatives: A comprehensive review of green synthetic strategies

Shah,

Patel

2024

Archiv der Pharmazie

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This review article offers an environmentally benign synthesis of 1,3,4‐oxadiazole derivatives, with a focus on sustainable methodologies that have minimal impact on the environment. These derivatives, known for their diverse applications, have conventionally been associated with synthesis methods that utilize hazardous reagents and produce significant waste, thereby raising environmental concerns. The green synthesis of 1,3,4‐oxadiazole derivatives employs renewable substrates, nontoxic catalysts, and mild reaction conditions, aiming to minimize the environmental impact. Innovative techniques such as catalyst‐based, catalyst‐free, electrochemical synthesis, green‐solvent‐mediated synthesis, grinding, microwave‐mediated synthesis, and photosynthesis are implemented, providing benefits in terms of scalability, cost‐effectiveness, and ease of purification. This review emphasizes the significance of sustainable methodologies in the synthesis of 1,3,4‐oxadiazole and boots for continued exploration in this research domain.

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Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease

Cited by 7 publications

References 44 publications

The mechanism of ferroptosis and its related diseases

The mechanism of ferroptosis and its related diseases

Prediction Model of Flavonoids Content in Ancient Tree Sun−Dried Green Tea under Abiotic Stress Based on LASSO−Cox

Eco‐friendly approaches to 1,3,4‐oxadiazole derivatives: A comprehensive review of green synthetic strategies

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