Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease

Shen, Zhen-Bao; Meng, Hua-Wen; Meng, Xian-She; Lv, Ze-Kun; Fang, Mengyuan; Zhang, Lang-Lang; Lv, Zhi-Lin; Li, Musen; Liu, Ankang; Han, Jihong; Li, Qing-Shan; Duan, Yajun

doi:10.1016/j.ejmech.2023.115417

Cited by 6 publications

(1 citation statement)

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“…The up-regulation of DMT1 ensuing from α-Syn overexpression also exerts a profound influence on the enhancement of iron uptake and the dysfunction of iron metabolism evidenced in PD [ 521 ]. Furthermore, the distorted expression and functionality of proteins involved in iron homeostasis have been detected in PD, further substantiating the association between iron dysregulation and the disease [ 504 , 509 , 510 , 522 , 523 ].…”

Section: Ferroptosis In Pathologiesmentioning

confidence: 84%

The mechanism of ferroptosis and its related diseases

Feng,

Tang,

Wang

et al. 2023

Mol Biomed

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Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of cellular metabolism, oxidative stress, and disease pathology. We have witnessed a mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological and pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, and traumatic tissue injuries. By unraveling the intricate underpinnings of the molecular machinery, pivotal contributors, intricate signaling conduits, and regulatory networks governing ferroptosis, researchers aim to bridge the gap between the intricacies of this unique mode of cellular death and its multifaceted implications for health and disease. In light of the rapidly advancing landscape of ferroptosis research, we present a comprehensive review aiming at the extensive implications of ferroptosis in the origins and progress of human diseases. This review concludes with a careful analysis of potential treatment approaches carefully designed to either inhibit or promote ferroptosis. Additionally, we have succinctly summarized the potential therapeutic targets and compounds that hold promise in targeting ferroptosis within various diseases. This pivotal facet underscores the burgeoning possibilities for manipulating ferroptosis as a therapeutic strategy. In summary, this review enriched the insights of both investigators and practitioners, while fostering an elevated comprehension of ferroptosis and its latent translational utilities. By revealing the basic processes and investigating treatment possibilities, this review provides a crucial resource for scientists and medical practitioners, aiding in a deep understanding of ferroptosis and its effects in various disease situations.

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