Design, synthesis and properties of a degradable polyurethane scaffold for meniscus regeneration

Heijkants, R. G. J. C.; Calck, R.V. van; Groot, J.H. de; Pennings, A. J.; Schouten, A.J.; Tienen, T.G. van; Ramrattan, Navin N.; Buma, P.; Veth, R.P.H.

doi:10.1023/b:jmsm.0000021114.39595.1e

Cited by 111 publications

(75 citation statements)

References 8 publications

(2 reference statements)

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“…These and other features need to be assessed in animal species prior to developing models for human meniscus repair. Canine models [16][17][18] have often been used due to similarity to human in vascular supply, anatomy, and biochemical composition. Other species that can be less costly and more available than dogs have also been used for meniscus repair, including sheep 16,19,20 and rabbit.…”

mentioning

confidence: 99%

Meniscus structure in human, sheep, and rabbit for animal models of meniscus repair

Chevrier

Nelea

Hurtig

et al. 2009

Journal Orthopaedic Research

183

174

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Meniscus injury is a frequently encountered clinical orthopedic issue and is epidemiologically correlated to osteoarthritis. The development of new treatments for meniscus injury is intimately related to the appropriateness of animal models for their investigation. The purpose of this study was to structurally compare human menisci to sheep and rabbit menisci to generate pertinent animal models for meniscus repair. Menisci were analyzed histologically, immunohistochemically, and by environmental scanning electron microscopy (ESEM). In all species, collagen I appeared throughout most menisci, but was absent from the inner portion of the tip in some samples. Collagen II was present throughout the inner main meniscal body, while collagen VI was found in pericellular and perivascular regions. The glycosaminoglycan-rich inner portion of menisci was greater in area for rabbit and sheep compared to human. Cells were rounded in central regions and more fusiform at the surface, with rabbit being more cellular than sheep and human. Vascular penetration in rabbit was confined to the very outermost region (1% of meniscus length), while vessels penetrated deeper into sheep and human menisci (11-15%). ESEM revealed a lamellar collagenous structure at the articulating surfaces of sheep and human menisci that was absent in rabbit. Taken together, these data suggest that the main structural features that will influence meniscus repair-cellularity, vascularity, collagen structure-are similar in sheep and human but significantly different in rabbit, motivating the development of ovine meniscus repair models. ß

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mentioning

confidence: 99%

Meniscus structure in human, sheep, and rabbit for animal models of meniscus repair

Chevrier

Nelea

Hurtig

et al. 2009

Journal Orthopaedic Research

183

174

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“…In this study, they compared the outcome of total meniscectomy with that of the implant of a PU-PCL total meniscal implant. This work followed a large series of in vitro and in vivo experimental studies on the development of this scaffold (Heijkants et al, 2005;Heijkants et al, 2004;van Tienen et al, 2009). The authors described satisfactory integration and fibrovascular tissue ingrowth into the implant with mild foreign body reaction.…”

Section: Total Meniscus Engineeringmentioning

confidence: 99%

Meniscus repair and regeneration: review on current methods and research potential

Scotti

Hirschmann

Antinolfi

et al. 2013

eCM

126

123

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Meniscus regeneration is an unsolved clinical challenge. Despite the wide acceptance of the degenerative consequences of meniscectomy, no surgical procedure has succeeded to date in regenerating a functional and long-lasting meniscal fibrocartilage. Research proposed a number of experimental approaches encompassing all the typical strategies of regenerative medicine: cellfree scaffolds, gene therapy, intra-articular delivery of progenitor cells, biological glues for enhanced bonding of reparable tears, partial and total tissue engineered meniscus replacement. None of these approaches has been completely successful and can be considered suitable for all patients, as meniscal tears require specific and patientrelated treatments depending on the size and type of lesion. Recent advances in cell biology, biomaterial science and bioengineering (e.g., bioreactors) have now the potential to drive meniscus regeneration into a series of clinically relevant strategies. In this tutorial paper, the clinical need for meniscus regeneration strategies will be explained, and past and current experimental studies on meniscus regeneration will be reported.

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“…[3][4][5] It is difficult to synthesize polyurethanes with monodisperse rigid segments via melt polymerization and also processing of these polymers without losing the uniformity of rigid segments is difficult. The dispersity of the rigid segments depends on the polymerization procedure.…”

Section: Introductionmentioning

confidence: 99%

“…In several studies, polyurethanes with uniform amide extenders were reported. [1,4,5] Versteegen [5] prepared block copoly(ether urea)s with amine-terminated prepolymer as flexible segments via protective group strategy and novel isocyanate chemistry. Segmented block copolymers with uniform rigid segments were synthesized by Van der Schuur et al [6] These polymers with monodisperse rigid segments had higher strength and toughness compared to analogous polymers with polydisperse rigid segments.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of polyurethane-urea-amide based on functionalized polystyrene

Kayalvizhi

Vakees

Suresh

et al. 2015

Designed Monomers and Polymers

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Hexamethylene diisocyanate (HMDI) based polyurethane-urea-amide (PUUA) is synthesized using diamide chain extenders and dihydroxy polystyrene. The rigid segment structure is HMDI-6X6-HMDI. The repeating molecular weight of the soft segment is varied from 2678 to 9202 g mol −1 using HMDI as a chain extender. The inherent viscosity of the polymer is 1.3-3.9 dL g −1 . Tm of PUUA varies between 239 and 265°C. The crystallinity of the amide segments is up to 70%. The polymers show single-stage decomposition temperature around 415°C. WAXS data confirm the semicrystalline nature of the polymer. The solvent resistivity of the polymer in chloroform is high due to high crystallinity of the hard segment.

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Design, synthesis and properties of a degradable polyurethane scaffold for meniscus regeneration

Cited by 111 publications

References 8 publications

Meniscus structure in human, sheep, and rabbit for animal models of meniscus repair

Meniscus structure in human, sheep, and rabbit for animal models of meniscus repair

Meniscus repair and regeneration: review on current methods and research potential

Synthesis and characterization of polyurethane-urea-amide based on functionalized polystyrene

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