Design, synthesis, and pharmacological evaluation of some 2-[4-morpholino]-3-aryl-5-substituted thiophenes as novel anti-inflammatory agents: generation of a novel anti-inflammatory pharmacophore

Iridium-catalyzed borylation of thiophenes: versatile, synthetic elaboration founded on selective C–H functionalization

“…2-halo-3,5-diarylthiophenes are quite rare. [59][60][61] Nevertheless, related compounds substituted at the 2-position exhibit interesting physical 62 and biological 63,64 properties.…”

Synthesis and antimicrobial activity of some novel 2-thienyl substituted heterocycles

“…Thiophene derivatives are important compounds [1][2][3][4][5][6][7][8] with considerable biological activity, such as antimicrobial [9,10], anti-inflammatory and analgesic activities [11][12][13][14]. Spiroindoles possessing a stereogenic center at C-3 [15,16] and thiazolidine derivatives have also wide applications in synthetic and medicinal chemistry [17][18][19][20][21].…”

Synthesis, Characterization and Biological Evaluation of Some Benzothiazole Derivatives as Potential Antimicrobial Agent.

“…Morever, thiazoles have found application in drug development for the treatment of hypertension 28 , schizophrenia 29 , HIV infections 30 , and as new inhibitors of bacterial DNA gyrase B 31 . In addition, a large number of thiophene derivatives have found to exhibit pharmacological activity [32][33][34] . Furthermore, diverse chemotherapeutic activities have ascribed to pyrazoles as antimicrobial [35][36] , antiparasitic 37 , antivirial 38 , and antineoplastic agents [39][40][41][42] .…”