Design, Synthesis, and Neuroprotective Effects of Novel Cinnamamide-Piperidine and Piperazine Derivatives
Jia-Yi Li,
Xin-Yan Peng,
Yi-Lei Huang
et al.
Abstract:In our previous studies, Fenazinel has shown good neuroprotective effects; however, when Fenazinel entered phase 1 clinical trials, it was associated with certain side effects. This study aimed to explore novel neuroprotective agents with higher potency and lower toxicity. Evidence suggested that cinnamic acid and its analogs may serve as promising lead compounds for stroke treatment. In this study, a series of Fenazinel derivatives were first synthesized with potential neuroprotective effects with fragments i… Show more
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