Design, Synthesis and Molluscicidal Activity of New Phosphorus Compounds Bearing Fluorine Substituted 1,2,4-Triazolo[3,2-c][1,2,4]triazine Derivatives

Abstract

Novel phosphorus compounds bearing fluorine substituted 1,2,4-triazolo[3,2-c][1,2,4]triazine derivatives have been synthesized, starting from ring closure reactions of 3-hydrazino-4-(4`- fluorophenyl)-5-(prydin-4`-yl)-1,2,4-trizole (4) with 1,2-bioxygen compounds followed by the treatment with functional phosphorus compounds. The new systems obtained were evaluated as molluscicidal targets against some snails. Structures of these targets were elucidated upon their elemental and spectral data.

Synthetic of Some New Fluorine Compounds Bearing 1,2,4-Triazine Moieties and the Related Hetero-Polycyclic Nitrogen Systems as Pharmacological Probes-Overview

“…Phosphorylation of both compounds 34 and 35 by warming with chloro-diphenyl phosphate in the presence the DMF afforded the N-(diphenyl phosphiteamino) 36 and 37, respectively (Scheme 15) [24].…”

“…Compound 36 and 37 can be used as molluscicidal agents against the snails which cause the disease of Bilharziasis according via the reported method [24],…”

“…As well as mostly, fluorine substituted 3-thioxo-1,2,4-triazinones showed a potential inhibitor as cyclin depend kinas (CDK2) for tumor cell damage [5] [6]. Recently, some fluorinated fused and isolated 1,2,4-triazines systems have been reported to have biocidal affect as molluscicidal agents against some snails [24]. In addition, many new fluorine compounds substituted by some or more heterobicyclic moieties, especially…”

Synthesis and antitumor activity of new isolated and fused heterobicyclic nitrogen systems containing 1,3,4-thiadiazole moiety derived from N1,N2-diaryl hydrazine compound

“…Most of the heterocyclic systems, for example,small units were active against more than 20 picomolar levels and showed significant inhibitory activity against tumor cells growth in liver cancer and/ or breast cancer in vivoapproachs [11][12][13][14]. It is interesting to note that substituted pyrazoles exhibited a wide range of biological, pharmacological, and medicinal activities [15][16][17][18][19][20]. Recently, functionally 1,2,4-triazine derivatives showed an important biological activity such as anti-HIV, and anticancer [21], antioxidant [22], anti-inflammatory [23], antifungal [24], herbicidal [25] and antibacterial [26,27] agents.…”

Synthesis and antitumor activity of new isolated and fused heterobicyclic nitrogen systems containing 1,3,4-thiadiazole moiety derived from N1,N2-diaryl hydrazine compound

“…Most of the heterocyclic systems, for example,small units were active against more than 20 picomolar levels and showed significant inhibitory activity against tumor cells growth in liver cancer and/ or breast cancer in vivoapproachs [11][12][13][14]. It is interesting to note that substituted pyrazoles exhibited a wide range of biological, pharmacological, and medicinal activities [15][16][17][18][19][20]. Recently, functionally 1,2,4-triazine derivatives showed an important biological activity such as anti-HIV, and anticancer [21], antioxidant [22], anti-inflammatory [23], antifungal [24], herbicidal [25] and antibacterial [26,27] agents.…”