Design, Synthesis and Molecular Properties Prediction of Novel Quinazoline Derivatives as Potent Antibacterial Agents

A palladium-catalyzed tandem reaction of 2-(quinazolinone-3(4H)-yl)benzonitriles with arylboronic acids has been developed, allowing access to a new class of 2-(4-arylquinazolin-2-yl)anilines that were often difficult to prepare using previous methods. In particular, the newly produced amino group is amenable to further synthetic elaborations, thereby broadening the diversity of the products. The structure of the newly synthesized 2-(4-arylquinazolin-2-yl)anilines was unambiguously confirmed by X-ray crystallography. Moreover, a possible mechanism for the formation of 2-(4-arylquinazolin-2-yl)anilines is discussed.

show abstract

Palladium‐Catalyzed Tandem Reaction of Quinazolinone‐Based Nitriles with Arylboronic Acids: Synthesis of 2‐(4‐Arylquinazolin‐2‐yl)anilines

Zhang

Shao

Gong

et al. 2018

Adv Synth Catal

View full text Add to dashboard Cite

show abstract

Pd-Catalyzed tandem reaction of N-(2-cyanoaryl)benzamides with arylboronic acids: synthesis of quinazolines

Zhu

Shao

et al. 2018

Org. Biomol. Chem.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Design, Synthesis and Molecular Properties Prediction of Novel Quinazoline Derivatives as Potent Antibacterial Agents

Cited by 2 publications

References 23 publications

Palladium‐Catalyzed Tandem Reaction of Quinazolinone‐Based Nitriles with Arylboronic Acids: Synthesis of 2‐(4‐Arylquinazolin‐2‐yl)anilines

Palladium‐Catalyzed Tandem Reaction of Quinazolinone‐Based Nitriles with Arylboronic Acids: Synthesis of 2‐(4‐Arylquinazolin‐2‐yl)anilines

Pd-Catalyzed tandem reaction of N-(2-cyanoaryl)benzamides with arylboronic acids: synthesis of quinazolines

Contact Info

Product

Resources

About