Design, Synthesis and Mode of Action of Some New 2-(4';-aminophenyl) benzothiazole Derivatives as Potent Antimicrobial Agents

Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance

“…Other benzothiazole derivatives acting as membrane perturbing agents able to depolarize the cytoplasmatic membrane of S. aureus and E. coli are compounds 29a , b and 30a , b ( Figure 13 ). 65 When assayed for their antibacterial activity against S. aureus (ATCC 25323), E. coli (ATCC 35218), P. aeruginosa (ATCC 27893), K. pneumonia (ATCC 31488), E. faecalis (clinical isolate), and S. typhi (MTCC 3216), the benzothiazole 29a , bearing a chlorine atom and a methoxy group on the phenyl ring, demonstrated the highest potency with MIC values in the range of 3.91–31.2 μg/mL. The effects of this series in perturbing the permeability of S. aureus and E. coli membrane was evaluated by using the cationic membrane potential-sensitive cyanine dye, which allows a determination of the alteration of membrane potential and the formation of pores, caused by the compounds, by an increase in fluorescence intensity.…”

“…coli are compounds 29a , b and 30a , b (Figure ). When assayed for their antibacterial activity against S. aureus (ATCC 25323), E.…”

Antimicrobial Properties of Orange (Citrus reticulata var. Kinnow) Peel Extracts against Pathogenic Bacteria

“…0.5 [~10 6 colony forming units CFU/ml]. (Singh et al, 2014) Determination of sensitivity of orange peel extract against pathogenic bacteria…”

“…The minimum inhibitory concentration (MIC) was defined as the lowest concentration where no viability was observed after 24 h on the basis of zones of growth. All the determinations were conducted in triplicates (Singh et al, 2014). The serial dilutions of the four different extracts have been tabulated in Table 1.…”

Investigations on the Anticancer Potential of Benzothiazole-Based Metallacycles

“…The benzothiazole scaffold has been extensively investigated for non-invasive diagnosis of Alzheimer's disease (Jia et al, 2015) as well as anti-inflammatory (Ban et al, 1998;Papadopoulou et al, 2005), antimicrobial (Singh et al, 2016), anti-allergic (Ban et al, 1998), analgesic (Baell et al, 2001;Westaway et al, 2008), antineoplastic (Chua et al, 2000;Starcevic et al, 2006;Caleta et al, 2009), topoisomerase I/II (Abdel-Aziz et al, 2004;Pinar et al, 2004;Mohmed et al, 2015), and tyrosine kinase inhibiting (Okaniwa et al, 2013;Gabr et al, 2015) properties. Apart from biological applications, C,N-coordination of 2phenylbenzothiazoles to Ir(III) are promising new candidates for the preparation of organic light-emitting diodes (OLEDs), due to their high quantum yield phosphorescence in yellow and orange (Li et al, 2014).…”