Design, synthesis and insecticidal activity of new 1,3,4-thiadiazole and 1,3,4-thiadiazolo[3,2-a]pyrimidine derivatives under solvent-free conditions

Synthesis and evaluation of larvicidal efficacy against C. pipiens of some new heterocyclic compounds emanated from 2‐cyano‐N′‐(2‐(2,4‐dichlorophenoxy)acetyl)acetohydrazide

“…The chlorinated compounds have been found to exhibit diverse biological activities such as antimicrobial, [8] anticancer, [9] Antifungal, [10] anti-obesity, Anti-proliferative, [11] inhibitory activity, [12] anti-diabetic activity, [13] antitubercular activity and Insecticidal Activities. [14][15][16][17][18] Chlorinated hydrocarbons and its derivatives boosted up pest control starting from the discovery of DDT in the beginning of the 19 th century. The development and utilization of insecticides have produced boundless avails for humankind as they kill undesirable insect pests by disruption of their vital processes via chemical action.…”

Diversification Via Coupling Reactions and Biological Activities of Pyrimidine Derivatives

“…With their rich history and importance to living organisms, pyrimidines will remain a major focus area in heterocyclic chemistry. According to a literature review, pyrimidine derivatives have a variety of biological actions, including those that are antibacterial, [12,13] antifungal, [14,15] anti-inflammatory, [16] anticancer, [17] insecticidal, [18] anti-tuberculotic, [19] and herbicidal. [20] Pyrimidines are extremely significant in the pharmaceutical sector in addition to their biological significance.…”

Synthesis of 3‐carene‐derived nanocellulose/1,3,4‐thiadiazole‐amide complexes with antifungal activity for plant protection

“…[17][18][19] According to the literatures, cyclopropane derivatives exhibited broad-spectrum bioactivities, such as antimicrobial, 20 antitumor, 21 insecticidal, 22 antiinflammatory, 23 and herbicidal activities. 24 However, both 1,3,4-thiadiazole and amide moieties are also the available pharmacophores in the discovery of novel drugs or agrochemicals, including insecticidal, 25 antiviral, 26 antifungal, 27,28 antitumor agents, 29 and herbicidal activities. 30 Herein, taking the earlier-mentioned clues into consideration along with the continuation of our interest in the works on natural product-based drug-delivery carriers, 8,[31][32][33][34] and bioactive compounds, 17,19,27,35,36 a series of novel nanopesticide carriers ETOCN-1-ETOCN-4 were prepared by TEMPO oxidation of bleached bagasse pulp and then esterification of TEMPO-oxidized cellulose nanofibers (TOCN) with intermediate 4 converted from 3-carene.…”

“…According to the literatures, cyclopropane derivatives exhibited broad‐spectrum bioactivities, such as antimicrobial, 20 antitumor, 21 insecticidal, 22 anti‐inflammatory, 23 and herbicidal activities 24 . However, both 1,3,4‐thiadiazole and amide moieties are also the available pharmacophores in the discovery of novel drugs or agrochemicals, including insecticidal, 25 antiviral, 26 antifungal, 27, 28 antitumor agents, 29 and herbicidal activities 30 …”