2022
DOI: 10.1016/j.bioorg.2022.105754
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Design, synthesis and in vivo evaluation of 1,4-dioxo-2-butenyl aryl amine derivatives as a promising anti-inflammatory drug prototype

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Cited by 4 publications
(3 citation statements)
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“…We showed that ZIM could be involved in inhibiting the inflammatory response, the involvement of Prostaglandins in the formation of edema, and reducing the recruitment of polymorphonuclear cells and the neurogenic phase of pain, making ZIM a good anti-inflammatory prototype . However, it is the first time ZIM has been reported as an efficient genotoxic agent since ZIM induced an increase in the frequency of both genomic and chromosomal damage.…”
Section: Discussionmentioning
confidence: 97%
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“…We showed that ZIM could be involved in inhibiting the inflammatory response, the involvement of Prostaglandins in the formation of edema, and reducing the recruitment of polymorphonuclear cells and the neurogenic phase of pain, making ZIM a good anti-inflammatory prototype . However, it is the first time ZIM has been reported as an efficient genotoxic agent since ZIM induced an increase in the frequency of both genomic and chromosomal damage.…”
Section: Discussionmentioning
confidence: 97%
“…The reaction of 1 with sodium acetate and acetic anhydride provided the maleimide 3 . Finally, the 4+2 cycloaddition reaction of 3 and cyclopentadiene provided the polycyclic compound 4 with a 3 h overall reaction time (Scheme B) …”
Section: Discussionmentioning
confidence: 99%
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