Design, synthesis and in vitro antiprotozoal activity of benzimidazole-pentamidine hybrids

Synthesis, spectral, antitumor, antioxidant and antimicrobial studies on Cu(II), Ni(II) and Co(II) complexes of 4-[(1H-Benzoimidazol-2-ylimino)-methyl]-benzene-1,3-diol

“…As biologically active compounds, benzimidazoles and their derivatives exhibited many biological applications such as antitumor [7], anticancer [8], antimicrobial [9], antifungal [10], and anti-inflammatory activities [11]. Imidazole, benzimidazole and their derivatives are part of an important class of N-heterocycles which can be excellent organic ligands to generate various complexes upon ligation [12][13][14][15][16][17][18][19][20][21].…”

Benzotriazoles and Indazoles Are Scaffolds with Biological Activity against Entamoeba histolytica

“…The second most active compounds have the cyclic system 3-(3-bromophenyl)-5-phenyl-1-(thiazolo [4,5-b] quinoxaline-2-yl)-2-pyrazoline (fJ0l9) with IC 50 values ranging from 3.2 to 0.100 µM, 17 followed by the benzimidazole-pentamidine hybrids (4ZQNH) with IC 50 values ranging from 12.053 to 0.109 µM. 18 others interesting active chemotypes are CP2TP and gY801 with IC 50 value ranges of 1.800 to 0.480 µM 6 and 9.560 to 0.510 µM, 19 respectively. table 2 shows the structures and biological activity of the newly tested compounds 1 to 12.…”

Chemotherapeutics of Neglected Waterborne Parasites: Current Status and Future Perspectives

“…In search of new drugs for therapy, recently a series of benzimidazolepentamidine hybrids have been synthesized. Few of these compounds have been shown to be active in submicromolar concentrations (54). Sulfurcontaining amino acids, e.g., cysteine has an important role in G. intestinalis survival by maintaining the cellular redox balance and providing the sulfur atom for the Fe-S clusters (55,56).…”